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- W601335890 abstract "症例は34歳男性．血便・肛門部痛を主訴に受診され，直腸診・内視鏡検査で下部直腸に腫瘤を認め，生検で高分化型腺癌と診断した．精査で外膜浸潤と所属リンパ節転移を認めたが，遠隔転移はなく，臨床病期はRbRa A P0 H0 M0 N2，cStage IIIbであった．括約筋温存と十分な剥離断端確保を目的に術前補助化学療法としてXELOXを開始した．2コース施行し原発巣・リンパ節は著明に縮小したが，有害事象としてgrade 3（CTCAE）の下痢・食思不振を認めた．2コースでXELOX終了し，腹腔鏡下直腸低位前方切除を施行した．病理組織検査では癌細胞を認めず病理学的完全奏効と診断した．術後補助化学療法としてXELOXを再開し，術後7ヵ月時点で再発徴候を認めていない．直腸癌に対する術前化学放射線療法は局所再発を低下させるが，術後合併症増加や排便機能などのQOL低下が指摘されている．本症例のように放射線治療を併用しない術前化学療法により完全奏効が得られれば，良好な予後とQOLが期待できると思われる．" @default.
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- W601335890 date "2013-01-01" @default.
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- W601335890 title "A Case of Locally Advanced Rectal Cancer in which Pathological CR was Achieved after XELOX Neoadjuvant Chemotherapy" @default.
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