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- W601337254 abstract "Since apolipoprotein E (apo E) has a significant role in lipoprotein metabolism, we investigated apo E phenotype involving plasma lipid levels, and the relationship between apo E and coronary artery stenosis. In addition, clinical features of type III hyperlipoproteinemia discovered recently were studied. For the six phenotype apo E 3/3, E 4/3, E 4/4, E 4/2, E 3/2 and E 2/2, the percentage distribution in 227 healthy appearing subjects were 74.4, 16.3, 1.8, 0.4, 7.0 and 0, respectively. As a result, the frequency of parent form (apo E 3/3) tended to be higher than that in western industrial countries. The incidence of hypercholesterolemics in each apo E phenotype revealed that the percentage of apo E 3/3, apo E 4/3+E 4/4 and apo E 3/2 were 6.5, 9.7 and 18.8, respectively. The number of hypercholesterolemics of the E 3/2 group was significantly higher than that of the E 3/3 group. On the basis of coronary angiography results, the patients were divided into two groups, coronary artery disease (CAD) (+) and CAD (-). No significant difference in the distribution of each apo E phenotype was found. Clinical findings, plasma lipids, lipoproteins and apolipoproteins in five cases with type III hyperlipoproteinemia associated with apo E 2/2 were investigated. The type III hyperlipoproteinemia seems to manifest itself when, in addition to the subjects bearing apo E 2/2, there is either environmental or genetic stimulation." @default.
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- W601337254 date "1986-01-01" @default.
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- W601337254 title "Apolipoprotein E Phenotype and Plasma Lipids" @default.
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- W601337254 doi "https://doi.org/10.5551/jat1973.14.4_809" @default.
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