Matches in SemOpenAlex for { <https://semopenalex.org/work/W601799750> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W601799750 abstract "We present the complete genomes of two human pathogens, Bartonella quintana (1,581,384 bp) and Bartonella henselae (1,931,047 bp). The two pathogens maintain several similarities in being transmitted by insect vectors, using mammalian reservoirs, infecting similar cell types (endothelial cells and erythrocytes) and causing vasculoproliferative changes in immunocompromised hosts. A primary difference between the two pathogens is their reservoir ecology. Whereas B. quintana is a specialist, using only the human as a reservoir, B. henselae is more promiscuous and is frequently isolated from both cats and humans. Genome comparison elucidated a high degree of overall similarity with major differences being B. henselae specific genomic islands coding for filamentous hemagglutinin, and evidence of extensive genome reduction in B. quintana, reminiscent of that found in Rickettsia prowazekii. Both genomes are reduced versions of chromosome I from the highly related pathogen Brucella melitensis. Flanked by two rRNA operons is a segment with similarity to genes located on chromosome II of B. melitensis, suggesting that it was acquired by integration of megareplicon DNA in a common ancestor of the two Bartonella species. Comparisons of the vector-host ecology of these organisms suggest that the utilization of host-restricted vectors is associated with accelerated rates of genome degradation and may explain why human pathogens transmitted by specialist vectors are outnumbered by zoonotic agents, which use vectors of broad host ranges." @default.
- W601799750 created "2016-06-24" @default.
- W601799750 creator A5050622835 @default.
- W601799750 date "2005-01-01" @default.
- W601799750 modified "2023-09-25" @default.
- W601799750 title "Lifestyle and Genome Evolution in Vector-Borne Bacteria : A Comparison of Three Bartonella Species" @default.
- W601799750 hasPublicationYear "2005" @default.
- W601799750 type Work @default.
- W601799750 sameAs 601799750 @default.
- W601799750 citedByCount "0" @default.
- W601799750 crossrefType "journal-article" @default.
- W601799750 hasAuthorship W601799750A5050622835 @default.
- W601799750 hasConcept C104317684 @default.
- W601799750 hasConcept C141231307 @default.
- W601799750 hasConcept C159047783 @default.
- W601799750 hasConcept C159654299 @default.
- W601799750 hasConcept C2522874641 @default.
- W601799750 hasConcept C2777535154 @default.
- W601799750 hasConcept C2777692091 @default.
- W601799750 hasConcept C2778256364 @default.
- W601799750 hasConcept C2780329011 @default.
- W601799750 hasConcept C2780414542 @default.
- W601799750 hasConcept C2780767784 @default.
- W601799750 hasConcept C2781429187 @default.
- W601799750 hasConcept C45189115 @default.
- W601799750 hasConcept C54355233 @default.
- W601799750 hasConcept C86803240 @default.
- W601799750 hasConceptScore W601799750C104317684 @default.
- W601799750 hasConceptScore W601799750C141231307 @default.
- W601799750 hasConceptScore W601799750C159047783 @default.
- W601799750 hasConceptScore W601799750C159654299 @default.
- W601799750 hasConceptScore W601799750C2522874641 @default.
- W601799750 hasConceptScore W601799750C2777535154 @default.
- W601799750 hasConceptScore W601799750C2777692091 @default.
- W601799750 hasConceptScore W601799750C2778256364 @default.
- W601799750 hasConceptScore W601799750C2780329011 @default.
- W601799750 hasConceptScore W601799750C2780414542 @default.
- W601799750 hasConceptScore W601799750C2780767784 @default.
- W601799750 hasConceptScore W601799750C2781429187 @default.
- W601799750 hasConceptScore W601799750C45189115 @default.
- W601799750 hasConceptScore W601799750C54355233 @default.
- W601799750 hasConceptScore W601799750C86803240 @default.
- W601799750 hasLocation W6017997501 @default.
- W601799750 hasOpenAccess W601799750 @default.
- W601799750 hasPrimaryLocation W6017997501 @default.
- W601799750 hasRelatedWork W125945654 @default.
- W601799750 hasRelatedWork W1542095737 @default.
- W601799750 hasRelatedWork W1972520421 @default.
- W601799750 hasRelatedWork W2031012252 @default.
- W601799750 hasRelatedWork W205621172 @default.
- W601799750 hasRelatedWork W2067613735 @default.
- W601799750 hasRelatedWork W2074003530 @default.
- W601799750 hasRelatedWork W2075603217 @default.
- W601799750 hasRelatedWork W2076137350 @default.
- W601799750 hasRelatedWork W2111771767 @default.
- W601799750 hasRelatedWork W2149990334 @default.
- W601799750 hasRelatedWork W2366660571 @default.
- W601799750 hasRelatedWork W251056979 @default.
- W601799750 hasRelatedWork W2896641307 @default.
- W601799750 hasRelatedWork W2923350145 @default.
- W601799750 hasRelatedWork W298548463 @default.
- W601799750 hasRelatedWork W338573484 @default.
- W601799750 hasRelatedWork W621838216 @default.
- W601799750 hasRelatedWork W77885290 @default.
- W601799750 hasRelatedWork W2169913920 @default.
- W601799750 isParatext "false" @default.
- W601799750 isRetracted "false" @default.
- W601799750 magId "601799750" @default.
- W601799750 workType "article" @default.