Matches in SemOpenAlex for { <https://semopenalex.org/work/W601979253> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W601979253 abstract "Alveolar Macrophages are central regulators of pulmonary immune responses, yet their regulatory functions are misunderstood. CD200, a transmembrane protein, and its receptor (CD200R) play a critical role in the resolution of inflammation, but their role in asthma is still unclear. CD200 is expressed on many cell types such as leukocytes, T cells, B cells, epithelial cells, and endothelial cells, while CD200R is expressed exclusively on myeloid cells including alveolar macrophages (AM) and mast cells (MC), which play a key role in asthma. Recent study showed that leukocytes from asthmatic patients express lower level of CD200 during exacerbations, suggesting a dysregulation of CD200 pathway. Thus, we investigated the modulation of CD200 expression on AM following allergen challenge and the inhibition of MC functions by AM CD200. Expression of CD200 and CD200R were measured on AM from naive and sensitized rats before and after allergen challenge using flow cytometry. AM modulation of antigen-stimulated MC was investigated in vitro using co-culture and MC degranulation and cytokine production. AM from naive and sensitized rats express similar level of CD200. However, allergen exposure increased CD200 expression on AM of naïve rats (that do not develop signs of asthma), but not on AM of sensitized rats (that develop experimental asthma). No difference between groups was observed for CD200R expression. Naive AM inhibited antigen-stimulated MC degranulation and cytokine production. The addition of neutralizing anti-CD200R antibody abrogated AM inhibitory effects. These results suggest that modulation of CD200 expression on AM could have an important role in asthma regulation." @default.
- W601979253 created "2016-06-24" @default.
- W601979253 creator A5009704046 @default.
- W601979253 creator A5065588213 @default.
- W601979253 creator A5087769278 @default.
- W601979253 creator A5091050096 @default.
- W601979253 creator A5060323624 @default.
- W601979253 date "2015-04-01" @default.
- W601979253 modified "2023-09-27" @default.
- W601979253 title "Alveolar macrophages express membrane CD200 that inhibits mast cell activation" @default.
- W601979253 doi "https://doi.org/10.1096/fasebj.29.1_supplement.lb614" @default.
- W601979253 hasPublicationYear "2015" @default.
- W601979253 type Work @default.
- W601979253 sameAs 601979253 @default.
- W601979253 citedByCount "0" @default.
- W601979253 crossrefType "journal-article" @default.
- W601979253 hasAuthorship W601979253A5009704046 @default.
- W601979253 hasAuthorship W601979253A5060323624 @default.
- W601979253 hasAuthorship W601979253A5065588213 @default.
- W601979253 hasAuthorship W601979253A5087769278 @default.
- W601979253 hasAuthorship W601979253A5091050096 @default.
- W601979253 hasConcept C1491633281 @default.
- W601979253 hasConcept C185592680 @default.
- W601979253 hasConcept C203014093 @default.
- W601979253 hasConcept C2779655021 @default.
- W601979253 hasConcept C2779726688 @default.
- W601979253 hasConcept C55493867 @default.
- W601979253 hasConcept C86803240 @default.
- W601979253 hasConcept C95444343 @default.
- W601979253 hasConceptScore W601979253C1491633281 @default.
- W601979253 hasConceptScore W601979253C185592680 @default.
- W601979253 hasConceptScore W601979253C203014093 @default.
- W601979253 hasConceptScore W601979253C2779655021 @default.
- W601979253 hasConceptScore W601979253C2779726688 @default.
- W601979253 hasConceptScore W601979253C55493867 @default.
- W601979253 hasConceptScore W601979253C86803240 @default.
- W601979253 hasConceptScore W601979253C95444343 @default.
- W601979253 hasIssue "S1" @default.
- W601979253 hasLocation W6019792531 @default.
- W601979253 hasOpenAccess W601979253 @default.
- W601979253 hasPrimaryLocation W6019792531 @default.
- W601979253 hasRelatedWork W1982386486 @default.
- W601979253 hasRelatedWork W1991837449 @default.
- W601979253 hasRelatedWork W2014623953 @default.
- W601979253 hasRelatedWork W2032492283 @default.
- W601979253 hasRelatedWork W2070820421 @default.
- W601979253 hasRelatedWork W2171015276 @default.
- W601979253 hasRelatedWork W2319367083 @default.
- W601979253 hasRelatedWork W2426190722 @default.
- W601979253 hasRelatedWork W2952340398 @default.
- W601979253 hasRelatedWork W4298845329 @default.
- W601979253 hasVolume "29" @default.
- W601979253 isParatext "false" @default.
- W601979253 isRetracted "false" @default.
- W601979253 magId "601979253" @default.
- W601979253 workType "article" @default.