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- W602191787 abstract "In some types of high LET radiation, the reversed dose rate effects are observed at a very low dose rate. To investigate whether the effect could be seen with low dose rate tritium radiation, a novel hyper-sensitive detection system was developed to detect Hprt-deficient mutations. This system uses Hprt deficient hamster fibroblast cells which carry a normal human X-chromosome, and appears to be able to detect a wide spectrum of mutations, even mutations affecting the expression of important genes in neighborhood of the Hprt gene. Exponentially growing cells were grown in medium containing different amounts of tritirated water (HTO) for appropriate periods. The frequency of Hprt-deficient mutations was then assayed by colony formation in medium containing 6-thioguanine. Differences in mutation frequencies induced by 1 Gy of tritium radiation were not observed within the range of dose rates used, suggesting that if a reverse dose-rate effect exists, it may not be observable with tritium radiation at dose rates over 0.04Gy/h. Molecular analysis of the Hprt locus in 6-TG resistant mutants induced by tritium showed that deletion sizes observed in the hamster cell’s human X-chromosome under these conditions is much smaller in cells exposed at 0.04Gy/h than in cells exposed at 0.9Gy/h." @default.
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- W602191787 date "2001-12-01" @default.
- W602191787 modified "2023-09-23" @default.
- W602191787 title "Somatic Mutation Caused by Low Dose Rate Tritium Radiation : Studies Using A Hyper-sensitive DetectionSystem" @default.
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