FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W602237078> ?p ?o ?g. }

• W602237078 abstract "The reticular-activating hypofrontality model of acute exercise (RAH) predicts exercise-induced hypoactivity in frontal cortex which mediates executive function. Connors Continuous Performance Test (CCPT) was used to investigate changes in executive function during- and post treadmill running in healthy volunteers (n=30, 15 male). In a randomized order, subjects performed the CCPT at rest, during low- (LI; 63% maximal heart rate; MHR) and moderate intensity (MI; 75% MHR). Separately, subjects then performed isocalorifically matched exercise bouts of LI, MI and high intensity interval training (HIT) consisting of 4x4 min with 90% MHR and 3 min recovery at 60-70% MHR. Repeated measures ANOVAs revealed main effects of exercise intensity for reaction time RT during- (p≤0.001) and post exercise (p≤0.0001). Subsequent analyses showed an overall increase of RT during exercise compared to rest (p≤0.005). RT decreased significantly from rest to post exercise levels in an exercise intensity dependent, linear fashion (p≤0.0001). Commission errors showed a non significant linear trend to increase both during (p=0.057), and post exercise (p=0.052) as a function of intensity. In a follow up study, we sought to relate observed exercise effects to frontal cortex activity through the use of transcranial direct current stimulation (tDCS) (n=4) and transcranial magnetic stimulation (TMS) over the dorsolateral prefrontal cortex (DLPFC). Prior to TMS stimulation cortical excitability was estimated post running through motor-evoked potentials (MEP) elicited from the primary motor cortex (M1) induced by single burst TMS and measured in the first dorsal interosseous (FDI) muscle using electromyography. At rest, inhibitory cathodal tDCS with left DLPFC cathode and right supraorbital anode led to improved reaction time and increased amount of commission errors, whereas anodal stimulatory tDCS in the immediate post exercise period was unable to recover the post exercise effect. Continuous theta burst stimulation over the left DLPFC post running further impaired inhibitory control and facilitated reaction time. Different findings during- and after- exercise suggests that potential contributing mechanisms such as computational and metabolic factors may be differentially active during these respective conditions. Furthermore, the fact that an inhibitory TMS protocol pronounced the post running effects even more and that we were able to mimic the reported RAH effects at rest with inhibitory frontal tDCS, but observed different patterns during exercise, suggests that the latter state cannot be fully explained by reducing activity in the left frontal cortex alone. Failure to modify the after exercise effect with stimulatory tDCS also supports an interplay of different factors and might emphasize the strong, robust effects of exercise that cannot simply be attenuated by current application. Increases in MEP post running for 35min paired with the observed performance decrements imply an excited state of M1 and might serve as an explanatory cross-link to central fatigue suggesting that a hypofrontal state might enhance the motor cortical drive to activate muscles." @default.
• W602237078 created "2016-06-24" @default.
• W602237078 creator A5039992148 @default.
• W602237078 date "2012-01-01" @default.
• W602237078 modified "2023-09-24" @default.
• W602237078 title "Investigation of an Exercise-Induced State of Hypofrontality: And its Potential Association with Central Fatigue" @default.
• W602237078 hasPublicationYear "2012" @default.
• W602237078 type Work @default.
• W602237078 sameAs 602237078 @default.
• W602237078 citedByCount "0" @default.
• W602237078 crossrefType "dissertation" @default.
• W602237078 hasAuthorship W602237078A5039992148 @default.
• W602237078 hasConcept C102959455 @default.
• W602237078 hasConcept C105795698 @default.
• W602237078 hasConcept C126322002 @default.
• W602237078 hasConcept C15744967 @default.
• W602237078 hasConcept C164705383 @default.
• W602237078 hasConcept C24998067 @default.
• W602237078 hasConcept C2778373776 @default.
• W602237078 hasConcept C2778581513 @default.
• W602237078 hasConcept C2780307956 @default.
• W602237078 hasConcept C33923547 @default.
• W602237078 hasConcept C71924100 @default.
• W602237078 hasConcept C99476002 @default.
• W602237078 hasConceptScore W602237078C102959455 @default.
• W602237078 hasConceptScore W602237078C105795698 @default.
• W602237078 hasConceptScore W602237078C126322002 @default.
• W602237078 hasConceptScore W602237078C15744967 @default.
• W602237078 hasConceptScore W602237078C164705383 @default.
• W602237078 hasConceptScore W602237078C24998067 @default.
• W602237078 hasConceptScore W602237078C2778373776 @default.
• W602237078 hasConceptScore W602237078C2778581513 @default.
• W602237078 hasConceptScore W602237078C2780307956 @default.
• W602237078 hasConceptScore W602237078C33923547 @default.
• W602237078 hasConceptScore W602237078C71924100 @default.
• W602237078 hasConceptScore W602237078C99476002 @default.
• W602237078 hasLocation W6022370781 @default.
• W602237078 hasOpenAccess W602237078 @default.
• W602237078 hasPrimaryLocation W6022370781 @default.
• W602237078 hasRelatedWork W2056347278 @default.
• W602237078 hasRelatedWork W2109318924 @default.
• W602237078 hasRelatedWork W2117641008 @default.
• W602237078 hasRelatedWork W2191741286 @default.
• W602237078 hasRelatedWork W2345302342 @default.
• W602237078 hasRelatedWork W2509720644 @default.
• W602237078 hasRelatedWork W2560429321 @default.
• W602237078 hasRelatedWork W2588112739 @default.
• W602237078 hasRelatedWork W2763313226 @default.
• W602237078 hasRelatedWork W2912979941 @default.
• W602237078 hasRelatedWork W2914169320 @default.
• W602237078 hasRelatedWork W2917870472 @default.
• W602237078 hasRelatedWork W2942870563 @default.
• W602237078 hasRelatedWork W2972114189 @default.
• W602237078 hasRelatedWork W3042406196 @default.
• W602237078 hasRelatedWork W3044095742 @default.
• W602237078 hasRelatedWork W3109925538 @default.
• W602237078 hasRelatedWork W3116315365 @default.
• W602237078 hasRelatedWork W3120902926 @default.
• W602237078 hasRelatedWork W3184826317 @default.
• W602237078 isParatext "false" @default.
• W602237078 isRetracted "false" @default.
• W602237078 magId "602237078" @default.
• W602237078 workType "dissertation" @default.