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- W60253376 abstract "The compound 3-phenylindole (3PI) is a particularly active antimicrobial which interacts with phospholipids in fungal mycelia membranes, and which strongly inhibits the uptake of phosphate into fungal mycelia. The physical effects of 3PI on ion transport across bilayer lipid membranes composed of phosphatidylcholine/cholesterol have been investigated using three lipophilic ions and one ion/carrier complex. It was found that 3PI increased the electrical conductivity induced by the lipophilic cation (tetraphenylarsonium) and by the positively charged complex (nonactin-K+) by several orders of magnttude whereas 3PI decreased the conductivity induced by the two lipophilic anions (tetraphenylborate, dipicrylamine) by a factor of less than ten. These conductivity changes are explained as a combination of changes in the electrostatic and in the non-electrostatic properties of the bilayer. The electrostatic potential of the bilayer interior was shown to decrease in the presence of 3PI, a phenomenon which was also confirmed by measurements of the surface potential of phosphatidylcholine/ cholesterol mono layers. The changes in non-electrostatic properties of the bilayer are qualitatively discussed in terms of increased bilayer fluidity or decreased bilayer thickness brought about by the presence of 3PI. The partition coefficient of the lipophilic anions, as determined by the voltage-step transient current technique, decreased slightly when 3PI was present in the aqueous phase." @default.
- W60253376 created "2016-06-24" @default.
- W60253376 creator A5037520425 @default.
- W60253376 date "2000-01-01" @default.
- W60253376 modified "2023-09-26" @default.
- W60253376 title "Physical effects of 3-phenylindole on ion transport across bilayer lipid membranes" @default.
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