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• W602612858 abstract "7198 Background: The five year survival rates for patients with stage I NSCLC treated with surgery alone range from 55% to 75%. Adjuvant chemotherapy improves survival in resected stage I NSCLC. There are no reliable markers (clinical or molecular) to predict recurrent disease. Methods: Patients included in this study had resection of stage I NSCLC from 1990 to 2000 at Barnes Jewish Hospital/Washington University School of Medicine. Our primary goal was to identify predictive factors for relapse in resected stage I NSCLC. Univariate analysis for associations with relapse was performed by X2 tests. A multivariate logistic regression model was fitted to identify independent predictors and construct prognostic groups. Results: 708 subjects were included in the analysis. Median duration of FU was 5.1 yrs. Characteristics: mean age 66 years (range 27–88); male: 53%; current or former smokers: 92%; T2: 49%. 87% had an anatomic resection with lobectomy being the most common procedure performed. Histology: adenocarcinoma (45%), squamous (36%) others (19%). 34% were poorly differentiated. Survival/Recurrence: Median and 5 yr survival rates were 5.2 yrs and 53%. Recurrence rates were 24% overall, 19% in T1, and 29% in T2. In the T2 subset, relapse rates were higher in patients with adenocarcinoma (35%) than in squamous cell type (21%). Four factors were significantly associated with relapse in the entire cohort of 708 patients: tumor size > 3cm (p<0.001, OR=2.2), invasion through visceral pleura (p=.004, OR=2.7), poor differentiation (p=.01, OR=1.7), and surgery other than lobectomy (p=.001, OR=2.1). Subjects were divided into prognostic groups according to the number of risk factors (RFs). Recurrence rates for 0, 1, 2, or 3 RF’s were 13%, 21%, 39%, and 50%. The relative risks of recurrence, as compared to no RFs, for 1, 2, or 3 RF’s were 1.68, 3.06, and 3.70. Conclusions: Combining RFs predicts relapse better than T stage in resected stage I NSCLC. This data should be prospectively validated. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca, Aventis, Bristol-Myers Squibb, Genentech, Lilly Oncology, Merck, Pfizer AstraZeneca, Aventis, Bristol-Myers Squibb, Ligand, Lilly Oncology, Pfizer" @default.
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• W602612858 date "2005-06-01" @default.
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• W602612858 title "Outcomes in 708 resected stage I non-small cell lung cancer (NSCLC) subjects and a prognostic index for relapse" @default.
• W602612858 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.7198" @default.
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