Matches in SemOpenAlex for { <https://semopenalex.org/work/W602901091> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W602901091 endingPage "109" @default.
- W602901091 startingPage "89" @default.
- W602901091 abstract "I. INTRODUCTION Restriction and modification of phages by bacteria were first described more than 40 years ago by Luria and Human (1952) for T-even phages and by Bertani and Weigle (1953) for the phages P2 and λ. The basic observation was that phages grown on one bacterial strain would grow poorly when tested on certain other related bacterial strains. Upon closer investigation, the poor growth was found to be an all or nothing affair. Most infected cells produced no phage at all; in the terminology that was adopted, the phages were restricted , although a few cells produced a normal yield of phage particles. The few phages that did result from the infection were modified so that they grew normally on the new host when tested in a second cycle of infection. Often, they were now restricted by the original host. The phenomenon of modification is Lamarckian rather than Mendelian in character since it is an adaptive response of the virus to the host that is lost when the virus is passaged through other cells. Some 10 years after the discovery of restriction and modification, the first of a series of papers from Arber’s laboratory appeared that offered a molecular explanation for the effect (Arber and Dussoix 1962; Dussoix and Arber 1962). Both restriction and modification were properties of the DNA of the infecting phage. Restriction was due to the action of a nuclease that recognized specific sequences in incoming DNA as a signal to cleave it; modification was due to..." @default.
- W602901091 created "2016-06-24" @default.
- W602901091 creator A5039816135 @default.
- W602901091 date "1993-01-01" @default.
- W602901091 modified "2023-09-24" @default.
- W602901091 title "3 The ATP-dependent Restriction Enzymes" @default.
- W602901091 doi "https://doi.org/10.1101/087969426.25.89" @default.
- W602901091 hasPublicationYear "1993" @default.
- W602901091 type Work @default.
- W602901091 sameAs 602901091 @default.
- W602901091 citedByCount "1" @default.
- W602901091 crossrefType "journal-article" @default.
- W602901091 hasAuthorship W602901091A5039816135 @default.
- W602901091 hasConcept C104317684 @default.
- W602901091 hasConcept C128319531 @default.
- W602901091 hasConcept C159047783 @default.
- W602901091 hasConcept C2776441376 @default.
- W602901091 hasConcept C2777271071 @default.
- W602901091 hasConcept C2910978944 @default.
- W602901091 hasConcept C523546767 @default.
- W602901091 hasConcept C54355233 @default.
- W602901091 hasConcept C547475151 @default.
- W602901091 hasConcept C552990157 @default.
- W602901091 hasConcept C86803240 @default.
- W602901091 hasConcept C89423630 @default.
- W602901091 hasConceptScore W602901091C104317684 @default.
- W602901091 hasConceptScore W602901091C128319531 @default.
- W602901091 hasConceptScore W602901091C159047783 @default.
- W602901091 hasConceptScore W602901091C2776441376 @default.
- W602901091 hasConceptScore W602901091C2777271071 @default.
- W602901091 hasConceptScore W602901091C2910978944 @default.
- W602901091 hasConceptScore W602901091C523546767 @default.
- W602901091 hasConceptScore W602901091C54355233 @default.
- W602901091 hasConceptScore W602901091C547475151 @default.
- W602901091 hasConceptScore W602901091C552990157 @default.
- W602901091 hasConceptScore W602901091C86803240 @default.
- W602901091 hasConceptScore W602901091C89423630 @default.
- W602901091 hasLocation W6029010911 @default.
- W602901091 hasOpenAccess W602901091 @default.
- W602901091 hasPrimaryLocation W6029010911 @default.
- W602901091 hasRelatedWork W1545338345 @default.
- W602901091 hasRelatedWork W1898552622 @default.
- W602901091 hasRelatedWork W1993400502 @default.
- W602901091 hasRelatedWork W1993449457 @default.
- W602901091 hasRelatedWork W1995047092 @default.
- W602901091 hasRelatedWork W1995245157 @default.
- W602901091 hasRelatedWork W2020514195 @default.
- W602901091 hasRelatedWork W2034130715 @default.
- W602901091 hasRelatedWork W2043275412 @default.
- W602901091 hasRelatedWork W2051171087 @default.
- W602901091 hasRelatedWork W2082868483 @default.
- W602901091 hasRelatedWork W2121500846 @default.
- W602901091 hasRelatedWork W2316392359 @default.
- W602901091 hasRelatedWork W2394557427 @default.
- W602901091 hasRelatedWork W2405321619 @default.
- W602901091 hasRelatedWork W2413134639 @default.
- W602901091 hasRelatedWork W2524400942 @default.
- W602901091 hasRelatedWork W3023728264 @default.
- W602901091 hasRelatedWork W48599239 @default.
- W602901091 hasRelatedWork W2245372966 @default.
- W602901091 hasVolume "25" @default.
- W602901091 isParatext "false" @default.
- W602901091 isRetracted "false" @default.
- W602901091 magId "602901091" @default.
- W602901091 workType "article" @default.