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- W60321617 abstract "This chapter concentrates on the ultrastructural features of Helicobacter pylori, with limited descriptions of some of the more unusual features seen in the other members of this genus. Certain aspects of the ultrastructural detail of the helicobacters, e.g., sheathed flagella and surface urease, have been implicated in their ability to survive in hostile environments such as the acidic gastric mucosa and their ability to induce disease. Generally it is considered that the spiral morphology and flagella are essential for colonization of gastric and intestinal mucus. By excluding flagellin, urease, and GroEL from their preparations, Doig and Trust were able to describe eight other outer membrane antigens of H. pylori, six of which were shown to be surface exposed. The action of the only monolactam tested, aztreonam, was found to be different, with this antibiotic inducing filamentation in the H. pylori cells, and this was attributed to the fact that this antibiotic was the only one tested that bound preferentially to a single penicillin-binding protein thought to be essential for helical morphology. The identification and characterization of ultrastructural features of H. pylori-infected tissue provide valuable insights into the pathogenesis of Helicobacter infection. However, the use of these characteristics to assess clinical outcomes of the infection is limited. Several bacterial toxins, such as Clostridium botulinum toxin or toxin A from Staphylococcus aureus, are known to cause alterations in cytoskeletal architecture." @default.
- W60321617 created "2016-06-24" @default.
- W60321617 creator A5001337090 @default.
- W60321617 creator A5047645943 @default.
- W60321617 date "2014-04-09" @default.
- W60321617 modified "2023-10-02" @default.
- W60321617 title "Morphology and Ultrastructure" @default.
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- W60321617 doi "https://doi.org/10.1128/9781555818005.ch6" @default.
- W60321617 hasPublicationYear "2014" @default.
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