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• W603516773 startingPage "90" @default.
• W603516773 abstract "Autophagy is a process by which eukaryotic cells degrade and recycle their intracellular components within lysosomes. Autophagy is induced by starvation to ensure survival of individual cells, and it has evolved to fulfill numerous additional roles in animals. Autophagy not only provides nutrient supply through breakdown products during starvation, but it is also required for the elimination of damaged or surplus organelles, toxic proteins, aggregates, and pathogens, and is essential for normal organelle turnover. Because of these roles, defects in autophagy have pathological consequences. Here we summarize the current knowledge of autophagy and related trafficking pathways in a convenient model: the compound eye of the fruit fly Drosophila melanogaster. In our review, we present a general introduction of the development and structure of the compound eye. This is followed by a discussion of various neurodegeneration models including retinopathies, with special emphasis on the protective role of autophagy against these diseases." @default.
• W603516773 created "2016-06-24" @default.
• W603516773 creator A5021941830 @default.
• W603516773 creator A5024574578 @default.
• W603516773 creator A5030181715 @default.
• W603516773 creator A5035163357 @default.
• W603516773 date "2016-03-01" @default.
• W603516773 modified "2023-10-17" @default.
• W603516773 title "iFly: The eye of the fruit fly as a model to study autophagy and related trafficking pathways" @default.
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