Matches in SemOpenAlex for { <https://semopenalex.org/work/W6035473> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W6035473 endingPage "478" @default.
- W6035473 startingPage "474" @default.
- W6035473 abstract "Objective: To investigate the expression of P-glycoprotein (P-gp), multidrug resistance-related protein (MRP), lung resistance-related protein (LRP), P53 and c-erbB-2 in untreated non-small cell lung cancer (NSCLC) and their relationship with each other. Methods: The expression of P-gp, MRP, LRP, P53 and c-erbB-2 was detected in the carcinoma tissues of 78 NSCLC patients and 15 adjacent normal lung tissues (5 cm apart from tumors) by means of immunohistochemistry. Results: The positive rates of P-gp, MRP, LRP, P53 and c-erbB-2 in tumor tissues were 65.4%, 39.7%, 56.4%, 53.8% and 43.6%, respectively, all significantly higher than those in normal tissues(P＜0.05). There was also significant difference in MRP and LRP expression between different pathologic types of NSCLC (squamous cell carcinoma, adenocarcinoma, large cell carcinoma) (P=0.008 and ＜0.001, respectively). Expression of LRP and P53 was also significantly different between different degrees of pathological differentiation (well, moderate, poor) (P=0.025 and 0.026, respectively). The expression of c-erbB-2 was correlated with those of P-gp, MRP, LRP and P53 (Spearman R=0.317, 0.401, 0.519 and 0.341, respectively; P=0.005, ＜0.001, ＜0.001 and =0.002, respectively); the expression of P53 was correlated with that of MRP (Spearman R=0.260, P=0.022); and the expression of LRP was correlated with that of MRP (Spearman R=0.371, P=0.001). Conclusion: Overexpression of P-gp, MRP, LRP, P53 and c-erbB-2 may play a cooperative role in the drug resistance and development of NSCLC." @default.
- W6035473 created "2016-06-24" @default.
- W6035473 creator A5012520231 @default.
- W6035473 creator A5068067982 @default.
- W6035473 creator A5074921724 @default.
- W6035473 creator A5075824884 @default.
- W6035473 creator A5076104759 @default.
- W6035473 creator A5083785830 @default.
- W6035473 date "2006-05-20" @default.
- W6035473 modified "2023-09-23" @default.
- W6035473 title "P-gp、MRP、LRP、P53及c-erbB-2在非小细胞肺癌中的表达" @default.
- W6035473 hasPublicationYear "2006" @default.
- W6035473 type Work @default.
- W6035473 sameAs 6035473 @default.
- W6035473 citedByCount "0" @default.
- W6035473 crossrefType "journal-article" @default.
- W6035473 hasAuthorship W6035473A5012520231 @default.
- W6035473 hasAuthorship W6035473A5068067982 @default.
- W6035473 hasAuthorship W6035473A5074921724 @default.
- W6035473 hasAuthorship W6035473A5075824884 @default.
- W6035473 hasAuthorship W6035473A5076104759 @default.
- W6035473 hasAuthorship W6035473A5083785830 @default.
- W6035473 hasConcept C114851261 @default.
- W6035473 hasConcept C121608353 @default.
- W6035473 hasConcept C126322002 @default.
- W6035473 hasConcept C133936738 @default.
- W6035473 hasConcept C142724271 @default.
- W6035473 hasConcept C204232928 @default.
- W6035473 hasConcept C2776256026 @default.
- W6035473 hasConcept C2777546739 @default.
- W6035473 hasConcept C2777714996 @default.
- W6035473 hasConcept C2778707650 @default.
- W6035473 hasConcept C2781182431 @default.
- W6035473 hasConcept C502942594 @default.
- W6035473 hasConcept C71924100 @default.
- W6035473 hasConcept C86803240 @default.
- W6035473 hasConcept C89423630 @default.
- W6035473 hasConceptScore W6035473C114851261 @default.
- W6035473 hasConceptScore W6035473C121608353 @default.
- W6035473 hasConceptScore W6035473C126322002 @default.
- W6035473 hasConceptScore W6035473C133936738 @default.
- W6035473 hasConceptScore W6035473C142724271 @default.
- W6035473 hasConceptScore W6035473C204232928 @default.
- W6035473 hasConceptScore W6035473C2776256026 @default.
- W6035473 hasConceptScore W6035473C2777546739 @default.
- W6035473 hasConceptScore W6035473C2777714996 @default.
- W6035473 hasConceptScore W6035473C2778707650 @default.
- W6035473 hasConceptScore W6035473C2781182431 @default.
- W6035473 hasConceptScore W6035473C502942594 @default.
- W6035473 hasConceptScore W6035473C71924100 @default.
- W6035473 hasConceptScore W6035473C86803240 @default.
- W6035473 hasConceptScore W6035473C89423630 @default.
- W6035473 hasIssue "5" @default.
- W6035473 hasLocation W60354731 @default.
- W6035473 hasOpenAccess W6035473 @default.
- W6035473 hasPrimaryLocation W60354731 @default.
- W6035473 hasVolume "27" @default.
- W6035473 isParatext "false" @default.
- W6035473 isRetracted "false" @default.
- W6035473 magId "6035473" @default.
- W6035473 workType "article" @default.