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- W603663419 abstract "New Jersey: Wiley; 2012 ISBN: 978-0-470-58492-7 Hard cover, 421 pages Cancer is a major disease of mortality and is afflicting more people today than ever before. In this book, Seyfried carefully elaborates a fascinating theory: cancer is not the results of genetic mutation, but is the results of metabolic dysregulation first suggested by Otto Warburg. As a gynecologic oncologist, I first had a great deal of skep ti cism regarding this concept. We have been taught the genetic origin as the cause of cancer and metabolic defects as a secondary phenomenon occurring from the genomic instability. This book begins with the question: “Why we lose the fights against cancer?” From an objective perspective, we haven’t won the “war” against cancer despite tremendous investigation in major pharmaceutical companies and in most leading medical centers throughout the world. This book suggests us to change our viewpoint regarding cancer. Seyfried insists that cancer has remained incurable largely due to a general misunderstanding of its origin, biology, and metabolism. This book explains that cancer is not a genetic disease, but rather a metabolic disease involving mitochondrial dysfunction and respiratory insufficiency. This book made me think about the fundamental concept of cancer“so what is the cause of cancer?” Otto Warburg was the first to explain the altered metabolism as the cause of tumor. The metabolic profile observed in cancer cells included increased consumption of glucose and glutamine, increased glycolysis, changes in the use of metabolic enzyme isoforms, and increased secretion of lactate. Respiration is the process by which cells use oxygen to obtain their energy through oxidative phosphorylation. According to Warburg’s theory, respiratory insufficiency is the origin of cancer. Seyfried backed up the theory with substantial evidence that all other characteristics of cancer arise either directly or indirectly from insufficient respiration. Based on this theory, the author suggested an interesting treatment strategy involving metabolic management. If canCancer as a metabolic disease: on the origin, management, and prevention of cancer" @default.
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- W603663419 date "2012-06-26" @default.
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- W603663419 title "Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer" @default.
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