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• W60387510 abstract "Insulin resistance (IR) is well documented in type 1 diabetes (T1D) and is theorized to relate to diabetes complications, including renal and coronary artery disease (CAD). The hyperinsulinemic-euglycemic clamp technique provides accurate assessment of IR, yet the laborious, costly, and invasive nature of this technique is often inappropriate for large investigations. Increasing use of the Estimated Glucose Disposal (eGDR) equation in T1D makes further examination of this equation desirable as it may be improved with additional assessments. Leg adiposity has been favorably associated with IR and cardiovascular risk, but whether this protective tendency is similar in T1D populations is unknown. This dissertation examines whether diabetes complications or additional clinical factors (i.e. regional adiposity distribution) contributes to the estimation of IR in T1D. Differences in regional adiposity, and the extent to which these differences influence IR, were examined in T1D and individuals without diabetes. Associations between CAD risk factors and regional adiposity were also investigated in individuals with T1D. No differences in IR were observed between T1D individuals with CAD or renal disease. All adiposity measures were detrimentally associated with IR, however, general obesity most strongly predicted IR in this population. Despite lower levels of adiposity, more severe IR was observed in individuals with T1D compared to non-diabetic individuals. Leg adiposity was favorably associated with presence of CAD, even after controlling for general obesity, but this association was only observed in non-diabetes and in T1D individuals who were obese. Trunk and leg fat displayed equal yet opposite associations with CAD risk factors and increasing leg adiposity was associated with decreased risk for the presence of CAD in females with T1D. This dissertation thus yields significant Public Health findings by providing evidence that IR is a prominent feature in T1D, is largely driven by adiposity, and can be estimated using clinical measures. Furthermore, the finding that leg adiposity was favorably associated with presence of CAD in individuals with T1D provides impetus to further study and underscores the complex association of adiposity with morbidity in T1D." @default.
• W60387510 created "2016-06-24" @default.
• W60387510 creator A5013041140 @default.
• W60387510 date "2009-09-28" @default.
• W60387510 modified "2023-09-27" @default.
• W60387510 title "Insulin resistance in type 1 diabetes: Determinants and clinical consequences" @default.
• W60387510 cites W102987255 @default.
• W60387510 cites W149215254 @default.
• W60387510 cites W1514817914 @default.
• W60387510 cites W1539328421 @default.
• W60387510 cites W1551246704 @default.
• W60387510 cites W1560657722 @default.
• W60387510 cites W1569867225 @default.
• W60387510 cites W1608704370 @default.
• W60387510 cites W1698271804 @default.
• W60387510 cites W175126830 @default.
• W60387510 cites W1760236651 @default.
• W60387510 cites W183233489 @default.
• W60387510 cites W1844698893 @default.
• W60387510 cites W189415718 @default.
• W60387510 cites W1901918943 @default.
• W60387510 cites W1924084714 @default.
• W60387510 cites W1946263363 @default.
• W60387510 cites W1946423577 @default.
• W60387510 cites W1950185295 @default.
• W60387510 cites W1964647826 @default.
• W60387510 cites W1965501665 @default.
• W60387510 cites W1966498669 @default.
• W60387510 cites W1966671518 @default.
• W60387510 cites W1970570839 @default.
• W60387510 cites W1971295965 @default.
• W60387510 cites W1975125777 @default.
• W60387510 cites W1975439501 @default.
• W60387510 cites W1976347558 @default.
• W60387510 cites W1976369579 @default.
• W60387510 cites W1976846109 @default.
• W60387510 cites W1976862640 @default.
• W60387510 cites W1977529722 @default.
• W60387510 cites W197775496 @default.
• W60387510 cites W1977797609 @default.
• W60387510 cites W1978012424 @default.
• W60387510 cites W1980502119 @default.
• W60387510 cites W1980868004 @default.
• W60387510 cites W1981779593 @default.
• W60387510 cites W1984382435 @default.
• W60387510 cites W1985006642 @default.
• W60387510 cites W1985030678 @default.
• W60387510 cites W1985704075 @default.
• W60387510 cites W1986401078 @default.
• W60387510 cites W1986440652 @default.
• W60387510 cites W1987303037 @default.
• W60387510 cites W1987560885 @default.
• W60387510 cites W1988800094 @default.
• W60387510 cites W1989333256 @default.
• W60387510 cites W1989337793 @default.
• W60387510 cites W1989391867 @default.
• W60387510 cites W1989654418 @default.
• W60387510 cites W1990809212 @default.
• W60387510 cites W1991123143 @default.
• W60387510 cites W1991456515 @default.
• W60387510 cites W1991967150 @default.
• W60387510 cites W1992000090 @default.
• W60387510 cites W1992116875 @default.
• W60387510 cites W1992229080 @default.
• W60387510 cites W1992483671 @default.
• W60387510 cites W1992748772 @default.
• W60387510 cites W1993841083 @default.
• W60387510 cites W1994204510 @default.
• W60387510 cites W1994281353 @default.
• W60387510 cites W1995838503 @default.
• W60387510 cites W1996026341 @default.
• W60387510 cites W1997063223 @default.
• W60387510 cites W1997434448 @default.
• W60387510 cites W1998378885 @default.
• W60387510 cites W1998436663 @default.
• W60387510 cites W1999599224 @default.
• W60387510 cites W1999745486 @default.
• W60387510 cites W2000484469 @default.
• W60387510 cites W2000600585 @default.
• W60387510 cites W2002222572 @default.
• W60387510 cites W2002681301 @default.
• W60387510 cites W2002954739 @default.
• W60387510 cites W2003950656 @default.
• W60387510 cites W2004208831 @default.
• W60387510 cites W2004421903 @default.
• W60387510 cites W2004925878 @default.
• W60387510 cites W2006342697 @default.
• W60387510 cites W2006428144 @default.
• W60387510 cites W2006638253 @default.
• W60387510 cites W2007549123 @default.
• W60387510 cites W2009044642 @default.
• W60387510 cites W2010495199 @default.
• W60387510 cites W2010644737 @default.
• W60387510 cites W2011054317 @default.
• W60387510 cites W2012070955 @default.
• W60387510 cites W2012943708 @default.
• W60387510 cites W2013128748 @default.
• W60387510 cites W2014047337 @default.
• W60387510 cites W2015605491 @default.
• W60387510 cites W2017360560 @default.

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