FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W603937746> ?p ?o ?g. }

• W603937746 endingPage "357" @default.
• W603937746 startingPage "352" @default.
• W603937746 abstract "Recognition of core histone components of chromatin along with chromosomal DNA by a class of small molecule modulators is worth examining to evaluate their intracellular mode of action. A plant alkaloid ellipticine (ELP) which is a putative anticancer agent has so far been reported to function via DNA intercalation, association with topoisomerase II and binding to telomere region. However, its effect upon the potential intracellular target, chromatin is hitherto unreported. Here we have characterized the biomolecular recognition between ELP and different hierarchical levels of chromatin. The significant result is that in addition to DNA, it binds to core histone(s) and can be categorized as a 'dual binder'. As a sequel to binding with histone(s) and core octamer, it alters post-translational histone acetylation marks. We have further demonstrated that it has the potential to modulate gene expression thereby regulating several key biological processes such as nuclear organization, transcription, translation and histone modifications." @default.
• W603937746 created "2016-06-24" @default.
• W603937746 creator A5021130835 @default.
• W603937746 creator A5051490532 @default.
• W603937746 creator A5057885946 @default.
• W603937746 creator A5071723603 @default.
• W603937746 creator A5079176198 @default.
• W603937746 creator A5084697774 @default.
• W603937746 creator A5090802552 @default.
• W603937746 date "2015-07-01" @default.
• W603937746 modified "2023-09-27" @default.
• W603937746 title "Recognition of chromatin by the plant alkaloid, ellipticine as a dual binder" @default.
• W603937746 cites W1590106897 @default.
• W603937746 cites W1974450480 @default.
• W603937746 cites W1979123201 @default.
• W603937746 cites W1989098286 @default.
• W603937746 cites W1995603674 @default.
• W603937746 cites W2000721637 @default.
• W603937746 cites W2001432049 @default.
• W603937746 cites W2005063559 @default.
• W603937746 cites W2010076254 @default.
• W603937746 cites W2015052870 @default.
• W603937746 cites W2016250348 @default.
• W603937746 cites W2027445597 @default.
• W603937746 cites W2029883255 @default.
• W603937746 cites W2030483280 @default.
• W603937746 cites W2032650901 @default.
• W603937746 cites W2041025847 @default.
• W603937746 cites W2050449365 @default.
• W603937746 cites W2059420133 @default.
• W603937746 cites W2061401805 @default.
• W603937746 cites W2064376910 @default.
• W603937746 cites W2068152651 @default.
• W603937746 cites W2074329127 @default.
• W603937746 cites W2076500958 @default.
• W603937746 cites W2081416676 @default.
• W603937746 cites W2082034956 @default.
• W603937746 cites W2082400627 @default.
• W603937746 cites W2083555350 @default.
• W603937746 cites W2087736976 @default.
• W603937746 cites W2089626640 @default.
• W603937746 cites W2103380615 @default.
• W603937746 cites W2146238208 @default.
• W603937746 cites W2159957200 @default.
• W603937746 cites W2163895770 @default.
• W603937746 cites W2333322967 @default.
• W603937746 doi "https://doi.org/10.1016/j.bbrc.2015.04.140" @default.
• W603937746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25960297" @default.
• W603937746 hasPublicationYear "2015" @default.
• W603937746 type Work @default.
• W603937746 sameAs 603937746 @default.
• W603937746 citedByCount "5" @default.
• W603937746 countsByYear W6039377462016 @default.
• W603937746 countsByYear W6039377462017 @default.
• W603937746 countsByYear W6039377462019 @default.
• W603937746 crossrefType "journal-article" @default.
• W603937746 hasAuthorship W603937746A5021130835 @default.
• W603937746 hasAuthorship W603937746A5051490532 @default.
• W603937746 hasAuthorship W603937746A5057885946 @default.
• W603937746 hasAuthorship W603937746A5071723603 @default.
• W603937746 hasAuthorship W603937746A5079176198 @default.
• W603937746 hasAuthorship W603937746A5084697774 @default.
• W603937746 hasAuthorship W603937746A5090802552 @default.
• W603937746 hasConcept C10058791 @default.
• W603937746 hasConcept C101152365 @default.
• W603937746 hasConcept C104317684 @default.
• W603937746 hasConcept C119157956 @default.
• W603937746 hasConcept C150194340 @default.
• W603937746 hasConcept C173681060 @default.
• W603937746 hasConcept C185592680 @default.
• W603937746 hasConcept C190727270 @default.
• W603937746 hasConcept C22709980 @default.
• W603937746 hasConcept C552990157 @default.
• W603937746 hasConcept C55493867 @default.
• W603937746 hasConcept C56428682 @default.
• W603937746 hasConcept C64927066 @default.
• W603937746 hasConcept C83640560 @default.
• W603937746 hasConcept C84772758 @default.
• W603937746 hasConcept C86803240 @default.
• W603937746 hasConcept C95444343 @default.
• W603937746 hasConceptScore W603937746C10058791 @default.
• W603937746 hasConceptScore W603937746C101152365 @default.
• W603937746 hasConceptScore W603937746C104317684 @default.
• W603937746 hasConceptScore W603937746C119157956 @default.
• W603937746 hasConceptScore W603937746C150194340 @default.
• W603937746 hasConceptScore W603937746C173681060 @default.
• W603937746 hasConceptScore W603937746C185592680 @default.
• W603937746 hasConceptScore W603937746C190727270 @default.
• W603937746 hasConceptScore W603937746C22709980 @default.
• W603937746 hasConceptScore W603937746C552990157 @default.
• W603937746 hasConceptScore W603937746C55493867 @default.
• W603937746 hasConceptScore W603937746C56428682 @default.
• W603937746 hasConceptScore W603937746C64927066 @default.
• W603937746 hasConceptScore W603937746C83640560 @default.
• W603937746 hasConceptScore W603937746C84772758 @default.
• W603937746 hasConceptScore W603937746C86803240 @default.
• W603937746 hasConceptScore W603937746C95444343 @default.
• W603937746 hasFunder F4320320768 @default.

• next