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- W60398880 abstract "Virus-induced gene silencing (VIGS) is an RNA silencing-based technique that employs recombinant viral vectors to transiently suppress plant gene expression in a sequence-specific manner. It exploits the innate antiviral mechanism in plants that can recognize unique features of viral nucleic acids and induce viral RNA degradation. Recombinant viruses, modified to express fragments of host genes, can activate the same pathway, leading to homology-based degradation of host gene transcript. As a tool, VIGS has many advantages over conventional techniques. The gene silencing is rapid, specific, easy to induce, and circumvents the need for stable transformants. VIGS can be used to study genes that may be lethal in stable knockouts and has the potential to silence single or multiple genes within a family. Several viruses have been modified for use as VIGS vectors in both dicot and monocot hosts with the tobacco rattle virus-based system proving to be the most popular choice for dicotyledonous plants. VIGS has been successfully employed in characterizing genes involved in many plant development and disease resistance pathways. The potential to use VIGS in a high-throughput fashion will make it a powerful tool for gene function assessment in the postgenomics era." @default.
- W60398880 created "2016-06-24" @default.
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- W60398880 date "2008-01-01" @default.
- W60398880 modified "2023-09-23" @default.
- W60398880 title "Virus-Induced Gene Silencing (VIGS)" @default.
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- W60398880 doi "https://doi.org/10.1016/b978-012374410-4.00578-1" @default.
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