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- W604058513 abstract "Objective To investigate the effect of hepatocyte growth factor(HGF)on the proliferation of human hepatocellular carcinoma cells.Methods Human hepatocellular carcinoma cells HepG2 were treated with HGF of different concentrations,and the cellular proliferation were measured by colorimetric BrdU cell proliferation enzyme-linked immunosorbent assay.The expression of cyclin dependent kinases inhibitors(p27,p21 and p18)was examined using Western blot and RT-PCR.Plasmids pcDNAp27 anti-sense was introduced into HepG2 cells and the effect of HGF on the proliferation in the clones with down-regulated p27 expression were observed.Results HGF inhibited the proliferation of hepatocelluar carcinoma cell in a dose-or period-dependent manner.The expression of p27,but not p21 and p18,was significantly induced by HGF.Furthermore,HGF did not suppress the proliferation of HepG2 cells transfected with antisense p27.Conclusion HGF could inhibit HepG2 cell proliferation by up-regulating p27 expression." @default.
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- W604058513 date "2009-01-01" @default.
- W604058513 modified "2023-09-23" @default.
- W604058513 title "The inhibitory effect of HGF on the proliferation of human hepatocellular carcinoma cells." @default.
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