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- W60419919 abstract "Background: Activation of volume-sensitive osmolyte and anion channels ( VSOACs ) has been shown to be involved in ischemic preconditioning (IPC) protection of isolated rabbit heart but the underlying molecular mechanisms remain unclear. Recent accumulative evidence strongly supports that ClC-3 may encode the VSOACs in the heart. Thus, ClC-3 knockout (KO) mice were used to directly test the hypothesis that activation of VSOACs may contribute to cardioprotection in both early and late IPC. Methods: Multiple approaches including telemetry ECG and echocardiography were used to assess the cardiovascular phenotype under normal, stressed (treadmill or ischemia), and in vivo early and late IPC conditions in age matched ClC-3 wild type (WT), heterozygous (HT) and KO littermates. Results: Targeted disruption of ClC-3 gene caused a decrease in the body weight (21.2±1.3 vs WT 28.3±1.2 g, n=68, P Early IPC significantly reduced infarct size caused by 30 min ischemia in all groups including ClC-3 KO mice (control 40.1±4.3% vs. IPC 22.7±3.7%, n=22, P Late IPC significantly reduced infarction in WT (22.9 ± 3.2% vs control 45.7±5.4%, n=22, P Conclusions: These results indicate that VSOACs may play an important cardioprotective role in the late IPC but not in the early IPC." @default.
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- W60419919 date "2006-10-31" @default.
- W60419919 modified "2023-09-27" @default.
- W60419919 title "Abstract 1425: VSOACs Play an Important Cardioprotective Role in Late Ischemic Preconditioning in Mouse Heart" @default.
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