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- W60420099 abstract "Microtubules are highly dynamic structures that comprise a- and b-tubulin heterodimers which are essential in mitosis. These features make microtubules an important target for many natural and synthetic anticancer drugs. Mutations in b-tubulin that affect microtubule polymer levels or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel. Moreover, aberrant expression of specific b-tubulin isotypes, namely bIII-tubulin as well as microtubule-binding proteins are now recognized as clinically important determinants in tumor aggressiveness and resistance to chemotherapy. More recently, it has been suggested that b-tubulins may also be linked to the tumorigenic phenotype of certain cancers such as non-small-cell lung cancer. Understanding the mechanisms whereby b-tubulins exert their effect on drug resistance and tumorigenesis are critical to the identification of novel drug targets and improvements in current therapies to increase the long-term survival of cancer patients." @default.
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- W60420099 date "2012-01-01" @default.
- W60420099 modified "2023-09-25" @default.
- W60420099 title "Microtubules, Drug Resistance, and Tumorigenesis" @default.
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- W60420099 doi "https://doi.org/10.1007/978-1-61779-788-0_12" @default.
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