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- W60448211 abstract "AbstractIn this chapter, the C-TMLE for the treatment-specific survival curve based on rightcensored data will be presented. It is common that one wishes to assess the effect of a treatment or exposure on the time it takes for an event to occur based on an observational database. Chapters 17 and 18 discussed the treatment-specific survival curve in RCTs. The TMLE presented there improves upon common methods for analyzing time-to-event data in robustness, efficiency, and interpretability of parameter estimates. Observational data differ from RCTs in that the exposure/treatment is not set according to a known mechanism. Moreover, in situations where there is dependent censoring the censoring mechanism is also unknown. As a consequence, in observational studies, the TMLE needs to estimate the treatment and censoring mechanism, and this needs to be done in such a way that the resulting targeted bias reduction carried out by the TMLE is fully effective." @default.
- W60448211 created "2016-06-24" @default.
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- W60448211 date "2011-01-01" @default.
- W60448211 modified "2023-09-24" @default.
- W60448211 title "C-TMLE for Time-to-Event Outcomes" @default.
- W60448211 doi "https://doi.org/10.1007/978-1-4419-9782-1_20" @default.
- W60448211 hasPublicationYear "2011" @default.
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