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- W60458544 abstract "An in vitro - in vivo model useful for investigating etiologic factors involved in cervical cancer is described. Cultures of normal human epithelial cells derived from foreskin or cervix were transfected with recombinant human papillomavirus (HPV) DNAs and a series of immortal cell lines were established. These cell lines contained integrated and transcriptionally active HPV DNAs, they were not tumorigenic in nude mice, and they retained the ability to undergo terminal squamous differentiation when tested at early passages. With continued propagation in culture the cells progressively became dysplastic and lost responsiveness to normal regulatory factors such as transforming growth factors beta 1 and 2 (TGFβ1 and 2). Transfection of immortal lines at early passage with activated v-Ha-ras or herpes simplex virus type 2 DNAs, which are often present in cervical cancer, led to malignant progression and formation of squamous carcinomas when cells were innoculated in nude mice. Thus, HPV-immortalized cervical cells are an appropriate model for studying the importance of specific environmental or host factors in cervical malignancy.KeywordsCervical CancerHuman Papilloma VirusHerpes Simplex Virus TypeCervical Intraepithelial NeoplasiaHuman Papilloma Virus InfectionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W60458544 date "1991-01-01" @default.
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- W60458544 title "Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfected with Human Papillomavirus DNAs" @default.
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- W60458544 doi "https://doi.org/10.1007/978-1-4612-0411-4_16" @default.
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