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- W60458812 abstract "The authors studied the efficacy of combination of carbamazepine with nootropic drugs on cognitive processes in patients with epilepsy in experiment in order to reduce the side effects of anticonvulsant therapy. Analysis of anticonvulsant effect of the combination of drugs was carried out on 36 white nonlinear rats of both sexes weighing 160-180 g by the method of maximum electroshock, and the analysis of antiamnestic effect using a model of retrograde amnesia on 80 white adult male rats weighing 160 200 g. For studying the mnemotropic activity of drug, the method of the conditioned reflex of active avoidance was used. The authors discovered that the isolated use of carbamazepine has the most negative influence on cognitive processes in animals, namely the formation of skill, memory engrams and consolidating memory trace as compared with the combined use of carbamazepine with neuroprotective drugs. It was found that the use of combinations of carbamazepine and nootropics in the experiment does not prevent the development of seizures completely, however, these combination can significantly reduce the duration of seizures (p" @default.
- W60458812 created "2016-06-24" @default.
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- W60458812 date "2013-01-01" @default.
- W60458812 modified "2023-10-16" @default.
- W60458812 title "Вивчення ефективності комбінації карбамазепіну з ноотропами на когнітивні процеси при епілепсії" @default.
- W60458812 hasPublicationYear "2013" @default.
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