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- W604604779 abstract "To clarify the possible mechanism of hyperlipidemia in uremia, we have determined serum lipid levels, serum apoprotein (apo) C-II and E levels and postheparin lipolytic activity which consists of lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) activities in 15 patients on maintenance hemodialysis and in 15 sex, age or serum triglyceride (TG) levels-matched normal controls. In addition, the relationship among various parameters in each group was investigated.There was a significant decrease in serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels and H-TGL activity in the patient group when compared to those of normal controls.Both serum apo C-II and apo E levels did not show significant changes between two groups regardless of age or sex.There was a significant positive relationship between serum apo C-II and apo E levels in two groups.In both groups, serum apo C-II and apo E levels showed a significant positive correlation to serum TG and TC levels. The correlation of TG to the apoproteins was much higher than that of TC.In the patient group, LPL activity showed a significant positive correlation to serum apo C-II and apo E levels but not in the control group. Moreover, the patient group had a significant negative relationship between H-TGL activity and serum apo E levels, while no significant changes were observed in the control group.These findings suggest that serum apo C-II and apo E levels may play an important role in the regulation of LPL and H-TGL activities in patients on maintenance hemodialysis." @default.
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- W604604779 date "1985-01-01" @default.
- W604604779 modified "2023-09-30" @default.
- W604604779 title "Serum Apoprotein C-II and Apoprotein E Levels and Postheparin Lipolytic Activity in Patients on Maintenance Hemodialysis" @default.
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- W604604779 doi "https://doi.org/10.5551/jat1973.12.6_1379" @default.
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