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- W60463505 abstract "Hapalociclamide, Aeruciclamides,and Microciclamides are bioactive hexacyclopeptides alternating in hydrophobic and hydrophilic (Ser, Thr and Cys) amino acids. 1 The side chains of these polar amino acids are heterocyclized to form azoles. Seeking to further explore their biological activity, our group began a program to develop a route to macrocyclic analogs of natural products with antimalarial or antitrypanosomal activity. 2 The long time required for solution synthesis of peptides encouraged us to explore the solid phase peptide synthesis (SPPS). This methodology diminishes the reaction time and the necessary amount of peptides could be obtained in excellent yields and purities." @default.
- W60463505 created "2016-06-24" @default.
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- W60463505 date "2013-12-01" @default.
- W60463505 modified "2023-09-30" @default.
- W60463505 title "Solid Phase Synthesis of Hexapeptides and Solution Macrocyclization to Obtain Antiparasitic Agents" @default.
- W60463505 doi "https://doi.org/10.5151/chempro-15bmos-bmos2013_2013822155639" @default.
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