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• W604676914 abstract "This book covers a wide field of classical muscle physiology and of the basics of myocardial function in health and disease. Lincoln Ford attempted – to put it in his own words – to ‘convey his enthusiasm for experiments and theories that have led to our current knowledge’. Though the text evolved from handouts given to undergraduates, it may indeed also be enjoyed by muscle researchers who are interested in the history of the subject on which they are working, as the book is full of personal recollections by one of the respected senior researchers in the field of muscle mechanics. Remember that Ford did much of his early work in the laboratories of Richard Podolsky and Sir Andrew Huxley. Naturally then some of the most interesting parts of the book cover such topics as calcium-induced calcium release and crossbridge theories, as well as mechanics but also some special phenomena e.g. length dependent activation and, of course, muscle energetics, in particular fatigue. The section on smooth muscle though is regrettably short and not quite balanced as are many other parts of the book. It has, for instance, rather little to say on the subject of muscle relaxation in relation to the sarcoplasmic reticulum and Wilhelm Hasselbach’s 1961 discovery of the calcium-pump is not even mentioned. On the other hand (and perhaps not surprisingly in view of the author’s athletic interests) some comparative aspects of muscle physiology and in particular the adaptation of muscle function to body size in different species are discussed in considerable detail – with special reference to the influence of specific body dimensions in athletic events. As is well known compared with large animals, small ones have a much higher metabolic rate and power output when normalised to body weight. Correspondingly fast twitch muscles of these animals have also a larger (normalised) unloaded shortening velocity than their counterparts in very large animals. Yet, all these muscles contain the same type of myosin i.e. fast skeletal myosin II. Naturally then the problem arises as to what species specific structural feature of the myosin molecule may account for the large kinetic differences between fast twitch muscle fibres (or for that matter, slow twitch fibres) of different species. Though interesting, this is to my knowledge still an open question whereas, on the other hand, there is now much insight into what aspects of myosin isoform structures make a fast twitch fibre faster than a slow twitch fibre of the same species. Rather regrettably then there is very little, if any, consideration of the molecular aspects of myosin structure or indeed of any other muscle protein. Notably the key note paper of Rayment and colleagues on myosin structure is not mentioned, nor is there any discussion of more recent studies e.g. on the role of the myosin lever arm in relation to the working stroke of the crossbridge and studies of single molecule mechanics are barely touched upon. Perhaps this is because the focus of the book is on muscle physiology and particularly on classical muscle mechanics, rather than on the biochemistry and the recent investigations of the molecular mechanism of muscle contraction. It is a personal account of muscle, written often from the perspective of work done in the author’s laboratory and is very readable, even entertaining, containing a number of stories and anecdotes about experiments that have led to an understanding of muscle and cardiac physiology. Thus, anyone interested in the history of the subject may well enjoy reading this volume." @default.
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• W604676914 date "2000-10-05" @default.
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• W604676914 title "Muscle Physiology and Cardiac Function" @default.
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