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- W60468491 abstract "Aim Our lab is validating the One Lambda C1q assay. As part of this process we are assessing pattern consistency between C1q and IgG single antigen bead results, and donor specific antibody. The ultimate goal is to improve the specificity of 1. unacceptable antigens listed in UNOS for sensitized solid organ recipients, and 2. antigens to avoid for platelet refractory patients. Methods 66 HLA class I and/or HLA class II positive patients were tested by single antigen IgG methods. (GenProbe LSA). All samples were tested with C1q assay (C1q, Labscreen, One Lambda). For stem cell transplants a CDC PRA was also performed (Gentrak). Results Results in Table 1 . Conclusions The LSA IgG assay clearly detects antibody specificities that do not bind complement C1q as only 68% were positive in both assays. Among regraft patients, the C1q assay demonstrated high specificity in confirming reactivity of the DSA identified in the LSA (IgG) assay. For the primary transplant group in this series, the overall correlation is lower, except among multiparous women. Unfortunately HLA typing is not available for most offspring of this group however C1q IgG did correlate with two known pregnancy exposures. Three samples from multiparous stem cell recipients were also tested in a CDC assay as their reactivity in both the IgG and C1q was so strong as to preclude identification of antigens to avoid. In all cases the CDC-PRA was >80%. Finally, and not surprisingly, the lowest correlation between IgG and C1q was apparent among ventricular assist device recipients. In our experience, serum from these patients often demonstrates non-specific reactivity that wanes over time. The lack of C1q activity supports that antibodies detected in LSA assays should not be presumed harmful." @default.
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- W60468491 date "2012-10-01" @default.
- W60468491 modified "2023-09-23" @default.
- W60468491 title "38-P" @default.
- W60468491 doi "https://doi.org/10.1016/j.humimm.2012.07.164" @default.
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