FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W604893299> ?p ?o ?g. }

• W604893299 endingPage "196" @default.
• W604893299 startingPage "190" @default.
• W604893299 abstract "Colloidal gold nanoparticles (AuNPs) of ~ 5 nm core size and Zeta-potential of − 35 mV, having absorption maximum and plasmon resonance in the range of 510–570 nm, were studied as a potential K+-channel opener in vascular smooth muscle (SM) cells. Experimental design of the study comprised SM contractile recordings. When externally applied to the organ bath, AuNPs (10− 6 − 3 × 10− 4 M) led to decrease in amplitude of norepinephrine-induced contractions in a concentration-dependent and endothelium-independent manner in SM thoracic aorta, with mean value of pD2 (− log EC50) 4.2 ± 0.03, Emax = 55 ± 4%. Being added to the bath solution in concentration of 10− 4 M, AuNPs significantly increased whole cell peak outward current at + 70 mV from 32 ± 2 pA/pF to 59 ± 5 pA/pF (n = 14, P < 0.05). External irradiation using a 5 mW/532 nm green laser, to facilitate plasmon resonance, led to an increment in the AuNPs-induced macroscopic outward potassium current (IK) from 59 ± 5 pA/pF to 74 ± 1 pA/pF (n = 10, P < 0.05). Paxilline (500 nM), when added to the external bathing solution, significantly decreased AuNPs-induced increment of IK in SM cells. Single channel recordings provided a direct confirmation of BKCa activation by AuNPs at the single-channel level. Application of AuNPs to the bath potentiated BKCa activity with a delay of 1–2 min, as was seen initially by more frequent channel openings followed by the progressive appearance of additional open levels corresponding to multiple openings of channels with identical single-channel amplitudes. Eventually, after 10–15 min in the presence of AuNPs and especially when combined with the green laser illumination, there was a massive increase in channel activity with > 10 channels evident. When irradiated by laser, AuNPs significantly increased the amplitude of maximal AuNPs-induced relaxation from 55 ± 5% to 85 ± 5% (n = 10, P < 0.05) while the sensitivity of SM to AuNPs was without changes. In summary, plasmonic AuNPs possess the ability to activate BKCa channel opening in vascular SM. Laser irradiation facilitates this effect due to local plasmon resonance that, in turn, further increases BKCa channel activity causing SM relaxation." @default.
• W604893299 created "2016-06-24" @default.
• W604893299 creator A5030021574 @default.
• W604893299 creator A5032579305 @default.
• W604893299 creator A5039619617 @default.
• W604893299 creator A5040500079 @default.
• W604893299 creator A5048599055 @default.
• W604893299 creator A5062439864 @default.
• W604893299 creator A5070413093 @default.
• W604893299 creator A5091616855 @default.
• W604893299 date "2015-09-01" @default.
• W604893299 modified "2023-10-17" @default.
• W604893299 title "Plasmonic gold nanoparticles possess the ability to open potassium channels in rat thoracic aorta smooth muscles in a remote control manner" @default.
• W604893299 cites W1968166964 @default.
• W604893299 cites W1972286938 @default.
• W604893299 cites W1975946513 @default.
• W604893299 cites W2007262967 @default.
• W604893299 cites W2019095191 @default.
• W604893299 cites W2058850923 @default.
• W604893299 cites W2061411427 @default.
• W604893299 cites W2062865173 @default.
• W604893299 cites W2115858827 @default.
• W604893299 cites W2129998516 @default.
• W604893299 cites W2151399844 @default.
• W604893299 cites W2167971085 @default.
• W604893299 cites W2189313949 @default.
• W604893299 doi "https://doi.org/10.1016/j.vph.2015.05.016" @default.
• W604893299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26044181" @default.
• W604893299 hasPublicationYear "2015" @default.
• W604893299 type Work @default.
• W604893299 sameAs 604893299 @default.
• W604893299 citedByCount "13" @default.
• W604893299 countsByYear W6048932992016 @default.
• W604893299 countsByYear W6048932992017 @default.
• W604893299 countsByYear W6048932992018 @default.
• W604893299 countsByYear W6048932992019 @default.
• W604893299 countsByYear W6048932992021 @default.
• W604893299 countsByYear W6048932992022 @default.
• W604893299 countsByYear W6048932992023 @default.
• W604893299 crossrefType "journal-article" @default.
• W604893299 hasAuthorship W604893299A5030021574 @default.
• W604893299 hasAuthorship W604893299A5032579305 @default.
• W604893299 hasAuthorship W604893299A5039619617 @default.
• W604893299 hasAuthorship W604893299A5040500079 @default.
• W604893299 hasAuthorship W604893299A5048599055 @default.
• W604893299 hasAuthorship W604893299A5062439864 @default.
• W604893299 hasAuthorship W604893299A5070413093 @default.
• W604893299 hasAuthorship W604893299A5091616855 @default.
• W604893299 hasConcept C104819515 @default.
• W604893299 hasConcept C106847996 @default.
• W604893299 hasConcept C110879396 @default.
• W604893299 hasConcept C113196181 @default.
• W604893299 hasConcept C12554922 @default.
• W604893299 hasConcept C126322002 @default.
• W604893299 hasConcept C155672457 @default.
• W604893299 hasConcept C171250308 @default.
• W604893299 hasConcept C178790620 @default.
• W604893299 hasConcept C185592680 @default.
• W604893299 hasConcept C192562407 @default.
• W604893299 hasConcept C2776864027 @default.
• W604893299 hasConcept C2779980429 @default.
• W604893299 hasConcept C43617362 @default.
• W604893299 hasConcept C49040817 @default.
• W604893299 hasConcept C517785266 @default.
• W604893299 hasConcept C71924100 @default.
• W604893299 hasConcept C83743174 @default.
• W604893299 hasConcept C86181022 @default.
• W604893299 hasConcept C86803240 @default.
• W604893299 hasConceptScore W604893299C104819515 @default.
• W604893299 hasConceptScore W604893299C106847996 @default.
• W604893299 hasConceptScore W604893299C110879396 @default.
• W604893299 hasConceptScore W604893299C113196181 @default.
• W604893299 hasConceptScore W604893299C12554922 @default.
• W604893299 hasConceptScore W604893299C126322002 @default.
• W604893299 hasConceptScore W604893299C155672457 @default.
• W604893299 hasConceptScore W604893299C171250308 @default.
• W604893299 hasConceptScore W604893299C178790620 @default.
• W604893299 hasConceptScore W604893299C185592680 @default.
• W604893299 hasConceptScore W604893299C192562407 @default.
• W604893299 hasConceptScore W604893299C2776864027 @default.
• W604893299 hasConceptScore W604893299C2779980429 @default.
• W604893299 hasConceptScore W604893299C43617362 @default.
• W604893299 hasConceptScore W604893299C49040817 @default.
• W604893299 hasConceptScore W604893299C517785266 @default.
• W604893299 hasConceptScore W604893299C71924100 @default.
• W604893299 hasConceptScore W604893299C83743174 @default.
• W604893299 hasConceptScore W604893299C86181022 @default.
• W604893299 hasConceptScore W604893299C86803240 @default.
• W604893299 hasLocation W6048932991 @default.
• W604893299 hasLocation W6048932992 @default.
• W604893299 hasOpenAccess W604893299 @default.
• W604893299 hasPrimaryLocation W6048932991 @default.
• W604893299 hasRelatedWork W2012670514 @default.
• W604893299 hasRelatedWork W2040894535 @default.
• W604893299 hasRelatedWork W2171006927 @default.
• W604893299 hasRelatedWork W2305188194 @default.
• W604893299 hasRelatedWork W2391784776 @default.
• W604893299 hasRelatedWork W2547019664 @default.

• next