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- W604963953 abstract "The genus Pleurotus comprises some of the most popular edible mushrooms dueto their favourable organoleptic and medicinal properties, vigorous growth andundemanding cultivation conditions. Pleurotus species contain a variety of secondarymetabolites including various phenolic compounds which have been said to act asexcellent antioxidants and possess antidiabetic activity. The antioxidant activity ofmycelial extract of nine Pleurotus species and antidiabetic activity for Pleurotuscitrinopileatus was investigated.The total phenolic content in mycelial extract of nine Pleurotus species wasassayed by Folin-Ciocalteau’s method while antioxidant activity was determined by twodifferent assays namely scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH)radical and ferric reducing antioxidant power (FRAP) assay. Mycelial extract of P.flabellatus exhibited the highest total phenolic content with 233.53±3.60 mg of GAEs/gof extract. Mycelial extract of P. sajor caju exhibited highest FRAP value with 28.20±0.19 μmol of FeSO4.7H2O equivalents/g of extract respectively. Mycelial extract of P.cystidiosus showed the most potent DPPH radical scavenging activity of 0.599 mg/ml atwhich 50% of DPPH radical were scavenged.The antidiabetic property of P. citrinopileatus was investigated by analysis offasting blood glucose level, fasting body weight, fasting insulin and catalase levelthroughout the 45 days of treatment, with a long term view towards the possible use ofthis mushroom in the treatment of diabetes. The results showed that fasting blood sugarlevel of STZ induced diabetic rats fed on Pleurotus citrinopileatus dropped by day 30and returned back to normal when compared to normal rats. Diabetic rats treated withmycelial extract of P. citrinopileatus showed an increase in body weight after 30 daysof treatment compared to diabetic rats treated with water.iiiBy the end of 45 days, no significant difference was observed in fasting insulinlevel between normal group and diabetic group of rats treated with high dose ofmycelial extract. Fasting catalase level marks no significant difference between normalrats and diabetic rats treated with mycelial extract of P. citrinopileatus. Histologicalsection of the kidney of STZ induced diabetes rats treated with 1000 mg/kg of mycelialextract showed a very mild congestion of glomeruli and interstitium stroma of cortex.Hence, the consumption of selected Pleurotus species grown in tropical conditions may have health promoting benefits as it is taken in appropriate dose as food supplement indaily life." @default.
- W604963953 created "2016-06-24" @default.
- W604963953 creator A5052789806 @default.
- W604963953 date "2011-01-01" @default.
- W604963953 modified "2023-09-26" @default.
- W604963953 title "Antioxidant activity of pleurotus species and antidiabetic activity of pleurotus citrinopileatus (singer) / Rushitha Sadasevevam" @default.
- W604963953 hasPublicationYear "2011" @default.
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