Matches in SemOpenAlex for { <https://semopenalex.org/work/W605523615> ?p ?o ?g. }
- W605523615 endingPage "202" @default.
- W605523615 startingPage "196" @default.
- W605523615 abstract "Reoviruses are widespread and infect a broad range of hosts. To date, no study has been reported on an aquatic reovirus receptor. By using viral overlay protein binding assay (VOPBA), swimming crab Portunus trituberculatus reovirus (SCRV) was found to bind to a protein of approximately 550 kDa. MALDI-TOF MS–MS analysis revealed that the protein shares the closest homology with β-tubulin. Mouse membrane proteins were tested by western blot with antibodies against the SCRV-binding protein and mouse tubulin, and uniform positive bands were obtained. The results indicated that the SCRV-binding protein was tubulin. The interaction between tubulin and SCRV was further confirmed with coimmunoprecipitation. SCRV infection in vitro could be blocked by a tubulin-specific antibody. The role of tubulin as a major cell surface protein has been reported previously. These findings suggest that tubulin mediates SCRV infection and may function as a receptor for SCRV. Swimming crab reovirus (SCRV) spread widely, caused losses of millions of dollars in crab cultivation industry in China. Up to now, no studies have been reported on reovirus receptor in aquatic organisms. This paper found that tubulin serves as a receptor for SCRV in swimming crab. It proposes a new drug target for preventing or controlling SCRV." @default.
- W605523615 created "2016-06-24" @default.
- W605523615 creator A5029233516 @default.
- W605523615 creator A5029771436 @default.
- W605523615 creator A5031128531 @default.
- W605523615 creator A5067028141 @default.
- W605523615 creator A5068661721 @default.
- W605523615 creator A5083345213 @default.
- W605523615 date "2015-11-01" @default.
- W605523615 modified "2023-09-24" @default.
- W605523615 title "Tubulin mediates Portunus trituberculatus reovirus infection" @default.
- W605523615 cites W1542714152 @default.
- W605523615 cites W1557166653 @default.
- W605523615 cites W1974045839 @default.
- W605523615 cites W1977270787 @default.
- W605523615 cites W1980284522 @default.
- W605523615 cites W1982097445 @default.
- W605523615 cites W1985286504 @default.
- W605523615 cites W1986731224 @default.
- W605523615 cites W1994345832 @default.
- W605523615 cites W1995967993 @default.
- W605523615 cites W1996028735 @default.
- W605523615 cites W1996243625 @default.
- W605523615 cites W1997921150 @default.
- W605523615 cites W2012486668 @default.
- W605523615 cites W2013027183 @default.
- W605523615 cites W2014407475 @default.
- W605523615 cites W2018362725 @default.
- W605523615 cites W2023037335 @default.
- W605523615 cites W2025363846 @default.
- W605523615 cites W2027165293 @default.
- W605523615 cites W2045173307 @default.
- W605523615 cites W2047584950 @default.
- W605523615 cites W2057084103 @default.
- W605523615 cites W2060287868 @default.
- W605523615 cites W2061100655 @default.
- W605523615 cites W2063983331 @default.
- W605523615 cites W2064573800 @default.
- W605523615 cites W2072801570 @default.
- W605523615 cites W2074596816 @default.
- W605523615 cites W2077936759 @default.
- W605523615 cites W2091010290 @default.
- W605523615 cites W2091183009 @default.
- W605523615 cites W2103409030 @default.
- W605523615 cites W2110811665 @default.
- W605523615 cites W2113663354 @default.
- W605523615 cites W2117279816 @default.
- W605523615 cites W2117551015 @default.
- W605523615 cites W2122170158 @default.
- W605523615 cites W2133495609 @default.
- W605523615 cites W2138623102 @default.
- W605523615 cites W2164991354 @default.
- W605523615 cites W2171667802 @default.
- W605523615 cites W2402867036 @default.
- W605523615 doi "https://doi.org/10.1016/j.aquaculture.2015.06.001" @default.
- W605523615 hasPublicationYear "2015" @default.
- W605523615 type Work @default.
- W605523615 sameAs 605523615 @default.
- W605523615 citedByCount "8" @default.
- W605523615 countsByYear W6055236152015 @default.
- W605523615 countsByYear W6055236152016 @default.
- W605523615 countsByYear W6055236152017 @default.
- W605523615 countsByYear W6055236152018 @default.
- W605523615 countsByYear W6055236152021 @default.
- W605523615 countsByYear W6055236152022 @default.
- W605523615 countsByYear W6055236152023 @default.
- W605523615 crossrefType "journal-article" @default.
- W605523615 hasAuthorship W605523615A5029233516 @default.
- W605523615 hasAuthorship W605523615A5029771436 @default.
- W605523615 hasAuthorship W605523615A5031128531 @default.
- W605523615 hasAuthorship W605523615A5067028141 @default.
- W605523615 hasAuthorship W605523615A5068661721 @default.
- W605523615 hasAuthorship W605523615A5083345213 @default.
- W605523615 hasConcept C104317684 @default.
- W605523615 hasConcept C159047783 @default.
- W605523615 hasConcept C159654299 @default.
- W605523615 hasConcept C170493617 @default.
- W605523615 hasConcept C203014093 @default.
- W605523615 hasConcept C20418707 @default.
- W605523615 hasConcept C2776415932 @default.
- W605523615 hasConcept C2778066766 @default.
- W605523615 hasConcept C505870484 @default.
- W605523615 hasConcept C55493867 @default.
- W605523615 hasConcept C71829478 @default.
- W605523615 hasConcept C84425145 @default.
- W605523615 hasConcept C86803240 @default.
- W605523615 hasConcept C95444343 @default.
- W605523615 hasConceptScore W605523615C104317684 @default.
- W605523615 hasConceptScore W605523615C159047783 @default.
- W605523615 hasConceptScore W605523615C159654299 @default.
- W605523615 hasConceptScore W605523615C170493617 @default.
- W605523615 hasConceptScore W605523615C203014093 @default.
- W605523615 hasConceptScore W605523615C20418707 @default.
- W605523615 hasConceptScore W605523615C2776415932 @default.
- W605523615 hasConceptScore W605523615C2778066766 @default.
- W605523615 hasConceptScore W605523615C505870484 @default.
- W605523615 hasConceptScore W605523615C55493867 @default.
- W605523615 hasConceptScore W605523615C71829478 @default.