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- W60576798 abstract "NuvaRing is a novel combined contraceptive vaginal ring that releases 15 μg of ethinylestradiol and 120 μg etonogestrel per day. Each ring is used for one cycle, comprising 3 weeks continuous use of the ring followed by a 1-week ring-free period. The contraceptive efficacy and safety of NuvaRing have been studied in a 1-year, open study conducted in 1145 women. Six pregnancies occurred in 12 109 cycles of exposure, giving a Pearl index of 0.65 (95% confidence interval (CI), 0.24–1.41). However, three of the six women violated the NuvaRing regimen in the cycle of conception. Compliance with the prescribed regimen was high, with criteria being fulfilled in 90.8% of cycles. During the 1 year of the study, 41% of the women did not experience any adverse events. The most frequently reported treatment-related adverse events were headache (6.6%), leukorrhea (5.3%) and vaginitis (5.0%). There was a low incidence of estrogen-related adverse events such as nausea (2.8%) and breast tenderness (1.9%). A total of 173 women (15.1%) discontinued due to an adverse event, with device-related events (comprising ring expulsion, foreign body sensation or coital problems) being the most commonly reported (2.6%). There were no clinically relevant changes in blood biochemistry, hematology, blood pressure, heart rate, body weight, physical examination or cervical cytology. In conclusion, NuvaRing is an effective contraceptive that is well tolerated, has a good safety profile and is not associated with unwanted effects on the cervix." @default.
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- W60576798 date "2002-12-01" @default.
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- W60576798 title "Contraceptive efficacy and tolerability with a novel combined contraceptive vaginal ring, NuvaRing" @default.
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- W60576798 doi "https://doi.org/10.1080/13625187.2002.11949331" @default.
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