Matches in SemOpenAlex for { <https://semopenalex.org/work/W605872435> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W605872435 abstract "A feed-forward loop (FFL) is one type of transcription network motifs studied in systems biology. So far, eight types of FFL based on their regulatory patterns have been identified. The majority of FFL found in transcription networks of biological systems have been identified to belong to coherent and incoherent type 1 FFL. Nevertheless, six FFLtypes (coherent and incoherent type 2, 3 and 4 FFL) are present in low frequencies in Escherichia coli. The persistence and not elimination of these “peculiar” FFL through natural selection is perplexing. One way to understanding this conundrum is to study the dynamics of these FFL and empirically study their relative abundance using public databases. To this end, data mining from RegulonDB and simulation using CellDesigner 4.2 were carried out. Coherent FFL shows delay in target gene expression upon the activation or repression by the activated forms of first and second transcription factors. Incoherent FFL shows acceleration of target gene expression that results in over production of target gene product. In particular, the acceleration of target gene expression in incoherent type 3 and 4 FFL are highly dependent on the promoter binding activity of the second transcription factor. We identified 84 of 1702 transcription factor-operon interactions in RegulonDB to be involved in FFL transcription networks in E. coli. A total of 28 FFL were identified, nine of them found to participate in biochemical processes such as maltose utilization, arabinose utilization and anaerobic respiration. The efficacy of peculiar FFLwas discussed in the context of these processes. We find that in silico simulation of FFLdynamics using CellDesigner 4.2 provide explicit results that are useful for guiding biological interpretation of important biological processes in E. coli. It is also a practical means of generating useful hypotheses in gene regulatory networks for experimental validation in the laboratory" @default.
- W605872435 created "2016-06-24" @default.
- W605872435 creator A5015463057 @default.
- W605872435 date "2012-01-01" @default.
- W605872435 modified "2023-09-27" @default.
- W605872435 title "Peculiar feed-forward loop network motifs in Escherichia coli / Kok Eng Piew" @default.
- W605872435 hasPublicationYear "2012" @default.
- W605872435 type Work @default.
- W605872435 sameAs 605872435 @default.
- W605872435 citedByCount "0" @default.
- W605872435 crossrefType "dissertation" @default.
- W605872435 hasAuthorship W605872435A5015463057 @default.
- W605872435 hasConcept C104317684 @default.
- W605872435 hasConcept C138885662 @default.
- W605872435 hasConcept C151730666 @default.
- W605872435 hasConcept C179926584 @default.
- W605872435 hasConcept C203075996 @default.
- W605872435 hasConcept C2779343474 @default.
- W605872435 hasConcept C41895202 @default.
- W605872435 hasConcept C54355233 @default.
- W605872435 hasConcept C547475151 @default.
- W605872435 hasConcept C70721500 @default.
- W605872435 hasConcept C86339819 @default.
- W605872435 hasConcept C86803240 @default.
- W605872435 hasConceptScore W605872435C104317684 @default.
- W605872435 hasConceptScore W605872435C138885662 @default.
- W605872435 hasConceptScore W605872435C151730666 @default.
- W605872435 hasConceptScore W605872435C179926584 @default.
- W605872435 hasConceptScore W605872435C203075996 @default.
- W605872435 hasConceptScore W605872435C2779343474 @default.
- W605872435 hasConceptScore W605872435C41895202 @default.
- W605872435 hasConceptScore W605872435C54355233 @default.
- W605872435 hasConceptScore W605872435C547475151 @default.
- W605872435 hasConceptScore W605872435C70721500 @default.
- W605872435 hasConceptScore W605872435C86339819 @default.
- W605872435 hasConceptScore W605872435C86803240 @default.
- W605872435 hasLocation W6058724351 @default.
- W605872435 hasOpenAccess W605872435 @default.
- W605872435 hasPrimaryLocation W6058724351 @default.
- W605872435 hasRelatedWork W1548356641 @default.
- W605872435 hasRelatedWork W1553327252 @default.
- W605872435 hasRelatedWork W1851128744 @default.
- W605872435 hasRelatedWork W1970103410 @default.
- W605872435 hasRelatedWork W2022133004 @default.
- W605872435 hasRelatedWork W2033160598 @default.
- W605872435 hasRelatedWork W2054578424 @default.
- W605872435 hasRelatedWork W2062057057 @default.
- W605872435 hasRelatedWork W2064201152 @default.
- W605872435 hasRelatedWork W2072642421 @default.
- W605872435 hasRelatedWork W2078170031 @default.
- W605872435 hasRelatedWork W2096327794 @default.
- W605872435 hasRelatedWork W2098222328 @default.
- W605872435 hasRelatedWork W2108420379 @default.
- W605872435 hasRelatedWork W2110699703 @default.
- W605872435 hasRelatedWork W2153978438 @default.
- W605872435 hasRelatedWork W2157865313 @default.
- W605872435 hasRelatedWork W2160319713 @default.
- W605872435 hasRelatedWork W2411366054 @default.
- W605872435 hasRelatedWork W609430750 @default.
- W605872435 isParatext "false" @default.
- W605872435 isRetracted "false" @default.
- W605872435 magId "605872435" @default.
- W605872435 workType "dissertation" @default.