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- W606270823 abstract "Objective. This study characterized the activation of platelet integrin αⅡbβ3 induced by two anti-human platelet te-traspanin monoclonal antibodies(mAbs),HI117 and SJ9A4.Methods. Using ^125I-labeled human fibrinogen (Fg) ,specific Fg binding to human platelets induced by HI117 and SJ9A4 was measured as indication of activation of platelet integrin αⅡbβ3 by the two mAbs. Results. HI117 and SJ9A4( 10μg/ml and 20μg/ml) induced evident specific Fg binding to human platelets,sug-gesting that the two mAbs evoked activation of platelet integrin αⅡbβ3. Further study indicated that HI117 and SJ9A4 induced integrin αⅡbβ3 activation independent of platelet Fc-receptors, and that HI117 and SJ9A4-induced integrin αⅡbβ3 activation was inhibited by sphingosing, aspirin, apyrase, and/or PGI2. Condusion. The anti-platelet tetraspanin(CD9) mAbs, HI117 and SJ9A4, can induce platelet integrin αⅡbβ3 acti-vation independent of Fc-receptors, Three signaling pathways, i, e. thromboxane, secreted ADP, and cAMP pathways may be involved in the process, with protein kinase C activation presumably being the common step of the three pathways." @default.
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- W606270823 date "2000-01-01" @default.
- W606270823 modified "2023-09-23" @default.
- W606270823 title "Anti-human platelet tetraspanin (CD9) monoclonal antibodies induce platelet integrin αIIbβ3 activation in a Fc receptor-independent fashion" @default.
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