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- W60642948 abstract "SUMMARY: A reaction in which cytidine 5′-diphosphate (CDP)-diglyceride and inositol are formed from 1-stearoyl, 2-arachidonoyl phosphatidylinositol and cytidine 5′-monophosphate (CMP) occurs readily in dialyzed microsomes from mouse pancreas. The reaction requires Mn 2+ and it is inhibited by each of the two products, CDP-diglyceride and myo-inositol. It is presumed to involve the back-reaction of CDP-diglyceride:inositol phosphatidyltransferase (phosphatidylinositol synthetase) (E.C.2.7.8.11). Evidence from [ 3 H ] cytidine incorporation in intact cells indicates that CDP-diglyceride is the first lipid product of acetylcholine-stimulated breakdown of phosphatidylinositol in mouse pancreas. Inositol has been shown previously to be the water-soluble product. The most likely mechanism for stimulated phosphatidylinositol breakdown is therefore the back-reaction of phosphatidylinositol synthetase - phosphatidylinositol + CMP → CDP-diglyceride + inositol. There appears to be the subsequent formation of phosphatidic acid from CDP-diglyceride." @default.
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- W60642948 date "1978-01-01" @default.
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- W60642948 title "THE MECHANISM OF STIMULATED PHOSPHATIDYLINOSITOL BREAKDOWN" @default.
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- W60642948 doi "https://doi.org/10.1016/b978-0-12-741750-9.50031-8" @default.
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