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• W60649410 abstract "The involvement of NO in genotoxicity and carcinogenic mechanisms may be varied. On one hand NO can form RNOS which can modify DNA. Most of these experiments were done under very high concentrations of NO and RNOS and may have little or nothing to do with in vivo mechanisms. However, NO can affect DNA specific repair systems even in whole cells at lower NO and RNOS concentrations which might enhance the damage of another agent. Though NO might alter DNA directly, the most likely involvement of its genotoxic action is through the increase in sensitivity to other mutagenic agents. From this discussion, it appears that the primary source of RNOS is from iNOS. Thus genotoxicity either by direct chemical alteration of DNA or interference with the repair system would be from an iNOS source." @default.
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• W60649410 date "1997-01-01" @default.
• W60649410 modified "2023-09-27" @default.
• W60649410 title "A discussion of mechanisms of NO genotoxicty: Implication of inhibition of DNA repair proteins" @default.
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• W60649410 doi "https://doi.org/10.1007/3-540-61992-5_8" @default.
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