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- W606553762 abstract "Objective:To investigate the genesis and development of influenza in molecule level,and to investigate the variation of Influenza HA in H1N1.Method:The nucleotide sequences of the new public and recent few years' influenza A H1N1 virus' hemagglutinin(HA) from all over the world were used as analysis objects in this research.The HA's glycosylation site,antigen determinant sites,amino acid sequences were analyze by bioinformatics software-CLUSTAL 1.83 and NetNGlyc 1.0 edc.The results reveal that there is high conservation area in HA of H1N1 between the recent influenza and the previous influenza.At last,the origin of influenza from the cladogram and verificate the some theory about resource were analyzed.Result:There is a new glycosylation site -NTT-in the position 249.Compared with the sequences of the human resource and the swine resource,there are 8 amino acid sites changed,which present in 6 antigen determinant sites.Conclusion:The increase of the glycosylation site,the change of amino acid sites lead to the change of the antigen determinant sites,the antigenic drift phenomenon which all could be the reason of transmissibility change." @default.
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- W606553762 date "2009-01-01" @default.
- W606553762 modified "2023-09-23" @default.
- W606553762 title "The variation analysis of influenza A H1N1'HA and the initial research of pestilence." @default.
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