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- W606690296 abstract "Refinements in therapy for patients with osteosarcoma are needed. Although the prognosis for children with osteosarcoma has improved dramatically in the past two decades, more than one third of children presenting without metastases will relapse after receiving the therapy currently available. Recently, many investigators have recommended the use of presurgical chemotherapy to deliver systemic treatment against micrometastases early in the course of therapy [1]. Although the approach with presurgical chemotherapy actually evolved to facilitate limb-sparing surgery by providing a window of time during which customized endoprosthetic devices could be fabricated, favorable responses in primary tumors of patients treated with presurgical chemotherapy encouraged investigators to approach all patients with presurgical chemotherapy to improve the overall outcome of these patients, whether or not they are candidates for limb-sparing operations. A number of theoretical advantages of presurgical chemotherapy are attractive. Since children undergoing orthopedic surgery spend several weeks recovering from their operation to allow for wound healing prior to the administration of chemotherapy, a period of several weeks is spent without treatment of their known micrometastatic disease. Such a delay is likely to be most critical early in treatment when the burden of micrometastatic disease is high; the administration of presurgical chemotherapy immediately after biopsy but before definitive surgery of the primary tumor thus allows for the earlier institution of systemic chemotherapy against micrometastases known to exist in virtually all patients at diagnosis, increasing the chance that these micrometastases might be eradicated." @default.
- W606690296 created "2016-06-24" @default.
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- W606690296 date "1993-01-01" @default.
- W606690296 modified "2023-09-30" @default.
- W606690296 title "Commentary on the use of presurgical chemotherapy" @default.
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- W606690296 doi "https://doi.org/10.1007/978-1-4615-3518-8_50" @default.
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