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- W60704706 abstract "This chapter discusses the production of selenium deficiency in the rat. Selenium is an essential nutrient for animals, and diets deficient in the element have been in use for a number of years. Most studies of selenium deficiency have been carried out in rats. An integral part of producing selenium deficiency for research purposes is an assessment of its severity. Feeding a selenium-deficient diet is the key for the production of selenium deficiency. Because animals can conserve their selenium stores when deprived of the element, it is customary to begin depletion in weanlings weighing about 50 g. Male rats are generally preferred because they have a higher selenium requirement than females. To produce very severe selenium deficiency, investigators have fed low-selenium diets to female rats from weaning and then to their off- spring. These “second generation” selenium-deficient rats grow very slowly, have sparse hair, and cannot reproduce. Another approach to producing very severe deficiency is to use an amino acid diet." @default.
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- W60704706 date "1987-01-01" @default.
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- W60704706 title "Production of selenium deficiency in the rat" @default.
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- W60704706 doi "https://doi.org/10.1016/0076-6879(87)43058-9" @default.
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