Matches in SemOpenAlex for { <https://semopenalex.org/work/W60752325> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W60752325 abstract "SULT2B1b is a novel SULT isoform with selectivity for the sulfation of 3β-hdroxysteroids and cholesterol. SULT2B1b has a unique 53 amino acid 3′-tail that undergoes Ser phosphorylation and is involved with nuclear translocation in BeWo choriocarcinoma cells. The human SULT2B1 gene encodes two messages utilizing different transcriptional start sites resulting in the incorporation of different first exons. Although both SULT2B1a and 2B1b messages are found in human tissues, only the SULT2B1b protein has been detected. SULT2B1b is present in nuclei of term placental synchiotrophoblast and normal and cancerous breast epithelial cells. The 3′-tail of SULT2B1b is required for nuclear localization in BeWo cells. Deletion of the unique 3′-tail prevents translocation to the nuclei. 2D electrophoresis indicates two charge variants of SULT2B1b in BeWo cells; however, the variants are not detected in SULT2B1b lacking the 3′-tail. Phosphorylation of Ser248 in the 3′-tail is associated with nuclear localization. Mutation of Ser248 to Ala blocks nuclear translocation of SULT2B1b. Treatment of BeWo cells expressing SULT2B1b with forskolin, a cAMP-dependent PKA inducer, increases phosphorylation and nuclear localization. SULT2B1b is the first SULT to show post-translational modification and nuclear localization suggesting a unique function in nuclei. Supported by PHS grant GM38953 to CNF." @default.
- W60752325 created "2016-06-24" @default.
- W60752325 creator A5010778963 @default.
- W60752325 creator A5046138198 @default.
- W60752325 creator A5048094144 @default.
- W60752325 creator A5071712264 @default.
- W60752325 date "2008-03-01" @default.
- W60752325 modified "2023-09-23" @default.
- W60752325 title "Post‐translational Modification and Nuclear Localization of Human Sulfotransferase (SULT) 2B1b" @default.
- W60752325 doi "https://doi.org/10.1096/fasebj.22.1_supplement.921.12" @default.
- W60752325 hasPublicationYear "2008" @default.
- W60752325 type Work @default.
- W60752325 sameAs 60752325 @default.
- W60752325 citedByCount "0" @default.
- W60752325 crossrefType "journal-article" @default.
- W60752325 hasAuthorship W60752325A5010778963 @default.
- W60752325 hasAuthorship W60752325A5046138198 @default.
- W60752325 hasAuthorship W60752325A5048094144 @default.
- W60752325 hasAuthorship W60752325A5071712264 @default.
- W60752325 hasConcept C104317684 @default.
- W60752325 hasConcept C11960822 @default.
- W60752325 hasConcept C138626823 @default.
- W60752325 hasConcept C153911025 @default.
- W60752325 hasConcept C185592680 @default.
- W60752325 hasConcept C2776879804 @default.
- W60752325 hasConcept C2780114586 @default.
- W60752325 hasConcept C29512474 @default.
- W60752325 hasConcept C49805395 @default.
- W60752325 hasConcept C55493867 @default.
- W60752325 hasConcept C59157529 @default.
- W60752325 hasConcept C86339819 @default.
- W60752325 hasConcept C86803240 @default.
- W60752325 hasConcept C95444343 @default.
- W60752325 hasConceptScore W60752325C104317684 @default.
- W60752325 hasConceptScore W60752325C11960822 @default.
- W60752325 hasConceptScore W60752325C138626823 @default.
- W60752325 hasConceptScore W60752325C153911025 @default.
- W60752325 hasConceptScore W60752325C185592680 @default.
- W60752325 hasConceptScore W60752325C2776879804 @default.
- W60752325 hasConceptScore W60752325C2780114586 @default.
- W60752325 hasConceptScore W60752325C29512474 @default.
- W60752325 hasConceptScore W60752325C49805395 @default.
- W60752325 hasConceptScore W60752325C55493867 @default.
- W60752325 hasConceptScore W60752325C59157529 @default.
- W60752325 hasConceptScore W60752325C86339819 @default.
- W60752325 hasConceptScore W60752325C86803240 @default.
- W60752325 hasConceptScore W60752325C95444343 @default.
- W60752325 hasFunder F4320308332 @default.
- W60752325 hasIssue "S1" @default.
- W60752325 hasLocation W607523251 @default.
- W60752325 hasOpenAccess W60752325 @default.
- W60752325 hasPrimaryLocation W607523251 @default.
- W60752325 hasRelatedWork W1547109494 @default.
- W60752325 hasRelatedWork W1569087667 @default.
- W60752325 hasRelatedWork W1951130496 @default.
- W60752325 hasRelatedWork W1981730547 @default.
- W60752325 hasRelatedWork W1989518283 @default.
- W60752325 hasRelatedWork W1998694857 @default.
- W60752325 hasRelatedWork W2012302802 @default.
- W60752325 hasRelatedWork W2042534572 @default.
- W60752325 hasRelatedWork W2155905348 @default.
- W60752325 hasRelatedWork W2168920565 @default.
- W60752325 hasVolume "22" @default.
- W60752325 isParatext "false" @default.
- W60752325 isRetracted "false" @default.
- W60752325 magId "60752325" @default.
- W60752325 workType "article" @default.