FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W607536472> ?p ?o ?g. }

• W607536472 endingPage "174" @default.
• W607536472 startingPage "169" @default.
• W607536472 abstract "Glomerulosclerosis is a common disorder in many types of chronic kidney diseases. Previous studies have shown that glomerular mesangial cells (MCs) play an important role in the pathogenesis of glomerulosclerosis. The ability of saikosaponin-d (SSd) to reduce the damage of kidney in progressive glomerulosclerosis has been demonstrated. In this study, the effects of saikosaponin-d on MC proliferation and synthesis of extracellular matrix proteins were investigated. Rat MCs were isolated from Wistar rats and cultured in Dulbecco's modified Eagle's medium. MCs were challenged with lipopolysacchorides and incubated with different concentrations of SSd. Cell proliferation and cytotoxicity were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), flow cytometry, and lactate dehydrogenase assays. Type IV collagen, fibronectin, and TGF-beta1 in the conditioned medium were measured. The expression of cyclin-dependent kinase 4, c-Jun, and c-Fos was determined by immunohistochemistry. At a concentration of 4 microg/mL or lower, SSd inhibited MC proliferation but did not cause cell death. SSd also inhibited lipopolysaccharide-induced secretion of type IV collagen, fibronectin, and TGF-beta1 in MCs. Additionally, SSd reduced the expression of CDK4, c-Jun, and c-Fos in MCs. We conclude that SSd inhibited MC proliferation and synthesis of extracullular matrix proteins through the downregulation of the CDK4, c-Jun, and c-Fos genes." @default.
• W607536472 created "2016-06-24" @default.
• W607536472 creator A5037805723 @default.
• W607536472 creator A5046208806 @default.
• W607536472 creator A5059596017 @default.
• W607536472 creator A5078164831 @default.
• W607536472 creator A5086213447 @default.
• W607536472 date "2007-04-01" @default.
• W607536472 modified "2023-09-26" @default.
• W607536472 title "Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteinsThis paper is one of a selection of papers in this Special Issue, entitled International Symposium on Recent Advances in Molecular, Clinical, and Social Medicine, and has undergone the Journal's usual peer-review process." @default.
• W607536472 cites W1624442503 @default.
• W607536472 cites W1969299399 @default.
• W607536472 cites W1970655448 @default.
• W607536472 cites W1972228232 @default.
• W607536472 cites W1989279844 @default.
• W607536472 cites W1993196935 @default.
• W607536472 cites W2007463241 @default.
• W607536472 cites W2014552722 @default.
• W607536472 cites W2024345240 @default.
• W607536472 cites W203309426 @default.
• W607536472 cites W2034958803 @default.
• W607536472 cites W2035230711 @default.
• W607536472 cites W2069366587 @default.
• W607536472 cites W2070246670 @default.
• W607536472 cites W2084662323 @default.
• W607536472 cites W2085676143 @default.
• W607536472 cites W2092468599 @default.
• W607536472 cites W2095277153 @default.
• W607536472 cites W2100398824 @default.
• W607536472 cites W2132980430 @default.
• W607536472 cites W2148911589 @default.
• W607536472 cites W2166012778 @default.
• W607536472 cites W2205247839 @default.
• W607536472 cites W2516329373 @default.
• W607536472 cites W4255937258 @default.
• W607536472 doi "https://doi.org/10.1139/o07-002" @default.
• W607536472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17534396" @default.
• W607536472 hasPublicationYear "2007" @default.
• W607536472 type Work @default.
• W607536472 sameAs 607536472 @default.
• W607536472 citedByCount "14" @default.
• W607536472 countsByYear W6075364722012 @default.
• W607536472 countsByYear W6075364722013 @default.
• W607536472 countsByYear W6075364722015 @default.
• W607536472 countsByYear W6075364722016 @default.
• W607536472 countsByYear W6075364722018 @default.
• W607536472 countsByYear W6075364722019 @default.
• W607536472 countsByYear W6075364722021 @default.
• W607536472 countsByYear W6075364722022 @default.
• W607536472 crossrefType "journal-article" @default.
• W607536472 hasAuthorship W607536472A5037805723 @default.
• W607536472 hasAuthorship W607536472A5046208806 @default.
• W607536472 hasAuthorship W607536472A5059596017 @default.
• W607536472 hasAuthorship W607536472A5078164831 @default.
• W607536472 hasAuthorship W607536472A5086213447 @default.
• W607536472 hasConcept C104317684 @default.
• W607536472 hasConcept C126322002 @default.
• W607536472 hasConcept C127561419 @default.
• W607536472 hasConcept C134018914 @default.
• W607536472 hasConcept C153911025 @default.
• W607536472 hasConcept C185592680 @default.
• W607536472 hasConcept C189165786 @default.
• W607536472 hasConcept C2777390665 @default.
• W607536472 hasConcept C2779131090 @default.
• W607536472 hasConcept C2779561371 @default.
• W607536472 hasConcept C2780091579 @default.
• W607536472 hasConcept C553184892 @default.
• W607536472 hasConcept C55493867 @default.
• W607536472 hasConcept C62112901 @default.
• W607536472 hasConcept C71924100 @default.
• W607536472 hasConcept C86492073 @default.
• W607536472 hasConcept C86803240 @default.
• W607536472 hasConcept C95444343 @default.
• W607536472 hasConceptScore W607536472C104317684 @default.
• W607536472 hasConceptScore W607536472C126322002 @default.
• W607536472 hasConceptScore W607536472C127561419 @default.
• W607536472 hasConceptScore W607536472C134018914 @default.
• W607536472 hasConceptScore W607536472C153911025 @default.
• W607536472 hasConceptScore W607536472C185592680 @default.
• W607536472 hasConceptScore W607536472C189165786 @default.
• W607536472 hasConceptScore W607536472C2777390665 @default.
• W607536472 hasConceptScore W607536472C2779131090 @default.
• W607536472 hasConceptScore W607536472C2779561371 @default.
• W607536472 hasConceptScore W607536472C2780091579 @default.
• W607536472 hasConceptScore W607536472C553184892 @default.
• W607536472 hasConceptScore W607536472C55493867 @default.
• W607536472 hasConceptScore W607536472C62112901 @default.
• W607536472 hasConceptScore W607536472C71924100 @default.
• W607536472 hasConceptScore W607536472C86492073 @default.
• W607536472 hasConceptScore W607536472C86803240 @default.
• W607536472 hasConceptScore W607536472C95444343 @default.
• W607536472 hasIssue "2" @default.
• W607536472 hasLocation W6075364721 @default.
• W607536472 hasLocation W6075364722 @default.
• W607536472 hasOpenAccess W607536472 @default.
• W607536472 hasPrimaryLocation W6075364721 @default.
• W607536472 hasRelatedWork W1994393119 @default.
• W607536472 hasRelatedWork W2005014760 @default.

• next