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- W60759901 abstract "Mitochondria are essential organelles of most eukaryotic cells including fungi, invertebrates, vertebrates, and plants. They perform various processes such as oxidative phosphorylation, the tricarboxylic acid cycle, fatty acid oxidation, the biosynthesis of various amino acids, the generation of iron-sulfur (Fe/S) clusters, and their insertion into apoproteins, as well as partial reactions of heme biosynthesis and the urea cycle. Reactions including membrane transport of proteins, peptides sugars, metabolites, vitamins, and lipids into and out of the organelle differ quite significantly from those operating in bacteria. Striking differences between mitochondria and bacteria also exist with respect to trafficking small molecules. To facilitate this task, mitochondria contain more than 30 so-called “carrier” proteins, which transport a variety of compounds across the inner membrane. Apparently, mitochondrial carrier proteins have replaced most of the versatile membrane transport functions performed by ATP-binding cassette (ABC) transporters of the bacterial ancestors of mitochondria. In present day bacteria such as Escherichia coli , more than 50 members of this large protein family are found, and they are crucial for transport into and out of the bacterial cytosol. This chapter summarizes the current knowledge of mitochondrial ABC transporters. It begins by addressing the properties and functions of the mitochondrial ABC transporters in S. cerevisiae . Then, the ABC transporters of mammalian cells are introduced and their (putative) functions in comparison to those defined for the yeast proteins. Finally, the chapter briefly reviews recent insights into plant mitochondrial ABC transporters and their (putative) functions." @default.
- W60759901 created "2016-06-24" @default.
- W60759901 creator A5046475529 @default.
- W60759901 creator A5082654778 @default.
- W60759901 date "2003-01-01" @default.
- W60759901 modified "2023-10-14" @default.
- W60759901 title "ABC TRANSPORTERS IN MITOCHONDRIA" @default.
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- W60759901 doi "https://doi.org/10.1016/b978-012352551-2/50026-3" @default.
- W60759901 hasPublicationYear "2003" @default.