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- W6078265 abstract "This chapter discusses conjugates of N-hydroxy compounds, which are the only type of metabolically formed conjugates with chemical reactivity leading to the formation of covalent bonds under physiological conditions. Metabolism of a drug or other foreign compound usually results in the termination of any biological or pharmacological action that the parent compound might have possessed. This is particularly true in the case of metabolic reactions involving conjugation. The metabolism of aromatic amines, however, represents an exception. Aromatic amines are among the most frequent causes of ferrihemoglobin formation in vivo, but in general, these compounds do not oxidize hemoglobin unless they undergo certain biochemical changes. The formation of ferrihemoglobin by aromatic amines is because of their conversion in vivo to the corresponding arylhydroxylamine by N-hydroxylation. In many cases, N-hydroxy metabolites of N-acyl derivatives of aromatic amines are further metabolized by conjugation reactions. Recent studies have shown that some conjugates of N-hydroxy compounds possess unexpected chemical reactivity with tissue nucleophiles, such as methionine and tryptophan residues in proteins, and with guanine residues in nucleic acid." @default.
- W6078265 created "2016-06-24" @default.
- W6078265 creator A5056911421 @default.
- W6078265 date "1970-01-01" @default.
- W6078265 modified "2023-10-15" @default.
- W6078265 title "CONJUGATES OF N-HYDROXY COMPOUNDS" @default.
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- W6078265 doi "https://doi.org/10.1016/b978-0-12-257601-0.50009-8" @default.
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