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- W60838861 abstract "For the development of the anti-obesity natural drug, the inhibitor of adipocyte differentiation was screened from Korean traditional medicinal plants. Phellodendri Cortex was selected as a candidate of adipocyte differentiation inhibitor. An inhibitory compound PC-4 was purified from the methanol (MeOH) extract of Phellodendri Cortex using silica gel and ODS RP-18 column chromatography and HPLC. PC-4 was obtained as yellow powder; UV (MeOH): 230, 260, 340 and 430 nm. The chemical structure of PC-4 was determined as an isoquionoline alkaloid, berberine, on the basis of various NMR experiments including . The PC-4 inhibited the differentiation of preadipocyte NIH-3T3 L1 cells at a concentration of ." @default.
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- W60838861 date "2003-01-01" @default.
- W60838861 modified "2023-09-23" @default.
- W60838861 title "Adipocyte Differentiation Inhibitor Isolated from the Barks of Phellodendron amurense" @default.
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