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- W60840160 abstract "Publisher Summary This chapter presents a study analyzing effects of glucocorticoids on muscle growth in young rats. Cortisone, at both low and high doses was administered to growing rats and its effects on the growth of six striated muscles studied. The muscles selected included the heart and both slow-twitch (soleus and diaphragm) and fast-twitch (plantaris, tibialis anterior and extensor digitorum longus, that is, EDL) skeletal muscles. Cortisone administration at the low dose produced no significant changes in the growth of either the whole animal or its individual muscles. In marked contrast to this, however, the high dose of cortisone completely suppressed whole-body growth in these young rats. During this latter treatment, slow-twitch muscles continued to accumulate protein, although this growth occurred at a greatly reduced rate. Fast-twitch muscles, however, exhibited no further growth whatsoever. From these results, it is clear that fast-twitch muscles are more susceptible than slow-twitch muscles to the catabolic effects of this steroid." @default.
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- W60840160 date "1981-01-01" @default.
- W60840160 modified "2023-09-26" @default.
- W60840160 title "EFFECTS OF GLUCOCORTICOIDS ON MUSCLE GROWTH IN YOUNG RATS" @default.
- W60840160 doi "https://doi.org/10.1016/b978-0-08-026817-0.50038-x" @default.
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