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- W608421269 abstract "Few studies have examined the effects of N,N-dipropyltryptamine (DPT) in vivo. In these studies, DPT was tested in a drug-elicited head twitch assay and in a conditioned head twitch assay in Swiss Webster mice. The effects of DPT were challenged with the selective serotonin (5-HT) 2A antagonist M100907, the 5-HT1A selective antagonist WAY-100635, and with depletion of central 5-HT produced via the synthesis inhibitor p-chlorophenylalanine (PCPA). DPT elicited dose-dependent effects in both assays, and the shape of the dose-effect curves was biphasic. WAY-100635 produced a parallel rightward shift in the dose-effect curves, indicative of surmountable antagonism, but the antagonist effects of M100907 were functionally insurmountable. The contribution of 5-HT2A receptors, 5-HT1A receptors, and central 5-HT in the mediation of these effects will be discussed. These studies supported by USPHS grants DA020645 and RR00165, and by the College on Problems of Drug Dependence." @default.
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- W608421269 date "2007-01-01" @default.
- W608421269 modified "2023-09-25" @default.
- W608421269 title "The hallucinogen‐like effects of N,N‐dipropyltryptamine are mediated by 5‐HT 1A and 5‐HT 2A receptors in the mouse" @default.
- W608421269 doi "https://doi.org/10.1096/fasebj.21.6.a780-c" @default.
- W608421269 hasPublicationYear "2007" @default.
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