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- W608429231 abstract "Objective To investigate the relationship of PCNA, CyclinD1, Ki-67 and P53 protein expression in epithelial tumors of lacrimal gland with it's clinical and pathological characterisitcs. Methods The tissue chips of 45 cases of lacrimal tumor tissues from 1985 to 2005 in Changzheng hospital were analyzed by the immunohistochemical method (Envision's) compared with 6 cases of normal lacrimal gland tissues. Result The ratios of postive cells of each immunity genes in the group of normal lacrimal tissues were: PCNA: 34.83% ± 12.64%, Ki-67: 3.83% ± 4.62%, CyclinD1: 5.50% ± 5.96%, P53: none; in the group of pleomorphic adenoma without recurrence were: PCNA: 52.19% ± 9.42%, Ki-67: 6.0% ± 6.51%, CyclinD1: 13.25% ± 12.69%, P53: 7.13% ± 7.57%; in the group of pleomorphic adenoma with recurrence were: PCNA: 56.20% ± 9.28%, Ki-67: 7.7% ± 8.35%, CyclinD1: 12.1% ± 10.95%, P53: 8.5% ± 7.11%; in the group of pleomorphic adenocarinoma were: PCNA: 82.0% ± 8.46%, Ki-67: 15.08% ± 11.41%, CyclinD1: 15.17% ± 11.92%, P53: 26.33% ± 9.44%; in the group of adenoid cystic carcinoma were: PCNA: 89.29v ± 5.24%, Ki-67: 16.86% ± 12.27%, CyclinD1: 17.14% ± 11.49%, P53: 22.29% ± 6.05%. The expression of PCNA, Ki-67, and P53 were singificantly different between benign lacrimal epithelial tumors and malignant epithelial tumors (p＜0.01), there were no statistic defferences of PCNA, Ki-67, CyclinD1 and P53 expressions between the pleomorphic adenoma without recurrence group and pleomorphic adenoma with recurence group. Conclusion the high expression of PCNA, Ki-67, CyclinD1 and P53 may be closely related to the occurrence, development and prognosis of epithelial tumors of lacrimal gland, the PCNA and P53 can be used as an index to identify malignant epithelial tumor." @default.
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- W608429231 date "2007-06-10" @default.
- W608429231 modified "2023-09-24" @default.
- W608429231 title "PCNA、Ki-67、CyclinD1、P53在泪腺上皮性肿瘤的表达及临床相关性研究" @default.
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