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• W609093387 abstract "It is said that two types of arterial lesions are known to be responsible for cerebral thrombosis: One is atherosclerosis, which affects “cortical arteries” called by Kameyama. The other type of lesion is fibrinoid necrosis, which affects “perforating arteries”. Therefore, patients with cerebral thrombosis are classified into 2 sub-groups namely the cortical artery (C) group and the perforating artery (P) group, based on the findings of computerized tomography and angiography.Serum lipoproteins and albumin concentrations were determined serially after onset of the stroke in patients with cerebral hemorrhage (H group) as well as cerebral thrombosis.In this study, total serum cholesterol (TC) was devided into two subfractions: α-cholesterol (α-C) and β-choleserol (β-C). HDL (α) farction was obtained by a phosphotungustate-Mg precipitation method, and the concentrations of total (α-C) and esterified cholesterol (α-CE) of this fraction were determined by enzymatic methods. Apolipoproteins were determined according to a single immuno-diffusion technique.The results were as follows.1) In the acute stage; within 4 days after onset of the stroke, the mean values of TC and α-C concentration and β/α-cholesterol (β/α-C) ratio in the H as well as in the P group were almost same levels as those of age-matched healthy controls.In the C group, there were increases of TC and decreases of α-Clevels, and the mean value of β/α-C ratio was significantly higher than that of the controls.2) In the convalescent stage; 4-8 weeks after onset of the stroke, the α-C and α-CE as well as apo A concentrations and LCAT activities were significantly lower in the C group than in the P group.In contrast, the mean values of apo B and β/α-C ratio were significantly higher in the C group than in the P group.3) There were significant differences of the α-C concentration and the β/α-C ratio between in the acute stage and the convalescent stage of cerebral thrombosis.4) The mean values of serum albumin concentration in each stage of stroke were significantly lower than those of age-matched controls.Hypercholesterolemia was observed in 46 percentage of patients with stroke and hypocholesterolemia in only a few patient.The results were suggested that these lipoprotein abnormalities might be due to the pathogenetic differences of cerebrovascular diseases.Hypoalbuminemia rather than hypocholesterolemia was more important risk factor to stroke in Japanese rural community." @default.
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• W609093387 date "1983-01-01" @default.
• W609093387 modified "2023-09-26" @default.
• W609093387 title "Serum Lipids and Apolipoproteins in Patients with Cerebrovascular Disease" @default.
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• W609093387 doi "https://doi.org/10.5551/jat1973.10.6_1041" @default.
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