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- W60944906 abstract "Shigellae cause intestinal disease by invading the colonic epithelium. Intracellular multiplication and intercellular spread of these organisms results in mucosal lesions and inflammation of the lamina propria (LaBrec et al. 1964). These lesions are usually confined to the colon, and they are responsible for the bloody, mucoid stools characteristic of bacillary dysentery. Naturally acquired shigella infections occur only in primates, and challenge studies have shown that the ID50 of Shigella flexneri 2a is approximately 5 × 103 colony forming units (CFU) (DuPont et al. 1969). Previous infection provides about 75% protection against a subsequent challenge with the ID50 of the homologous strain (Dupont et al. 1972); therefore, immunization against shigellosis is a theoretical possibility." @default.
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- W60944906 date "1989-01-01" @default.
- W60944906 modified "2023-10-17" @default.
- W60944906 title "Oral Shigella Vaccines" @default.
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- W60944906 doi "https://doi.org/10.1007/978-3-642-74529-4_22" @default.
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