FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W609537162> ?p ?o ?g. }

• W609537162 endingPage "1277" @default.
• W609537162 startingPage "1273" @default.
• W609537162 abstract "Cardiac fibrosis is one of the key structural changes of the hypertrophied left ventricle in hypertensive heart disease. Increased angiotensin II was found to be important in the hypertension related fibrosis, while the underlying mechanism is unknown. In this study, we found that angiotensin II dose-dependently increased the expression of Col1a1, Col3a1 and α-smooth muscle actin, which were blocked by ROS (reactive oxygen species) scavenger N-acetyl cysteine (NAC). Mechanistically, angiotensin II induced robust ROS generation, which in turn induced cytoplasmic translocation of RNA binding protein HuR. Cytoplasmic translocated HuR increased TGFβ pathway activity and subsequent collagen synthesis. In contrast, knockdown of HuR nearly blocked angiotensin II induced TGFβ activation and collagen synthesis. Taken together, we here identified that angiotensin II promotes collagen synthesis in cardiac fibroblast through ROS-HuR-TGFβ pathway." @default.
• W609537162 created "2016-06-24" @default.
• W609537162 creator A5026072443 @default.
• W609537162 creator A5049712015 @default.
• W609537162 creator A5051382165 @default.
• W609537162 creator A5058558768 @default.
• W609537162 creator A5061876736 @default.
• W609537162 creator A5064221229 @default.
• W609537162 date "2015-08-01" @default.
• W609537162 modified "2023-10-12" @default.
• W609537162 title "Cytoplasmic translocation of HuR contributes to angiotensin II induced cardiac fibrosis" @default.
• W609537162 cites W1970546936 @default.
• W609537162 cites W2016353229 @default.
• W609537162 cites W2020081155 @default.
• W609537162 cites W2020746336 @default.
• W609537162 cites W2025826819 @default.
• W609537162 cites W2031662595 @default.
• W609537162 cites W2032831426 @default.
• W609537162 cites W2033180466 @default.
• W609537162 cites W2044427990 @default.
• W609537162 cites W2049462796 @default.
• W609537162 cites W2051628797 @default.
• W609537162 cites W2068197222 @default.
• W609537162 cites W2074629755 @default.
• W609537162 cites W2125220365 @default.
• W609537162 cites W2125227867 @default.
• W609537162 cites W2132933646 @default.
• W609537162 cites W2152631271 @default.
• W609537162 cites W2162066324 @default.
• W609537162 cites W2162724888 @default.
• W609537162 cites W2398664613 @default.
• W609537162 doi "https://doi.org/10.1016/j.bbrc.2015.06.101" @default.
• W609537162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26093296" @default.
• W609537162 hasPublicationYear "2015" @default.
• W609537162 type Work @default.
• W609537162 sameAs 609537162 @default.
• W609537162 citedByCount "10" @default.
• W609537162 countsByYear W6095371622017 @default.
• W609537162 countsByYear W6095371622018 @default.
• W609537162 countsByYear W6095371622019 @default.
• W609537162 countsByYear W6095371622021 @default.
• W609537162 crossrefType "journal-article" @default.
• W609537162 hasAuthorship W609537162A5026072443 @default.
• W609537162 hasAuthorship W609537162A5049712015 @default.
• W609537162 hasAuthorship W609537162A5051382165 @default.
• W609537162 hasAuthorship W609537162A5058558768 @default.
• W609537162 hasAuthorship W609537162A5061876736 @default.
• W609537162 hasAuthorship W609537162A5064221229 @default.
• W609537162 hasConcept C104317684 @default.
• W609537162 hasConcept C126322002 @default.
• W609537162 hasConcept C134018914 @default.
• W609537162 hasConcept C138626823 @default.
• W609537162 hasConcept C173396325 @default.
• W609537162 hasConcept C185592680 @default.
• W609537162 hasConcept C190283241 @default.
• W609537162 hasConcept C198710026 @default.
• W609537162 hasConcept C2777420927 @default.
• W609537162 hasConcept C2778921608 @default.
• W609537162 hasConcept C2780559512 @default.
• W609537162 hasConcept C2908929049 @default.
• W609537162 hasConcept C48349386 @default.
• W609537162 hasConcept C55493867 @default.
• W609537162 hasConcept C71924100 @default.
• W609537162 hasConcept C84393581 @default.
• W609537162 hasConcept C86803240 @default.
• W609537162 hasConcept C95444343 @default.
• W609537162 hasConceptScore W609537162C104317684 @default.
• W609537162 hasConceptScore W609537162C126322002 @default.
• W609537162 hasConceptScore W609537162C134018914 @default.
• W609537162 hasConceptScore W609537162C138626823 @default.
• W609537162 hasConceptScore W609537162C173396325 @default.
• W609537162 hasConceptScore W609537162C185592680 @default.
• W609537162 hasConceptScore W609537162C190283241 @default.
• W609537162 hasConceptScore W609537162C198710026 @default.
• W609537162 hasConceptScore W609537162C2777420927 @default.
• W609537162 hasConceptScore W609537162C2778921608 @default.
• W609537162 hasConceptScore W609537162C2780559512 @default.
• W609537162 hasConceptScore W609537162C2908929049 @default.
• W609537162 hasConceptScore W609537162C48349386 @default.
• W609537162 hasConceptScore W609537162C55493867 @default.
• W609537162 hasConceptScore W609537162C71924100 @default.
• W609537162 hasConceptScore W609537162C84393581 @default.
• W609537162 hasConceptScore W609537162C86803240 @default.
• W609537162 hasConceptScore W609537162C95444343 @default.
• W609537162 hasFunder F4320321001 @default.
• W609537162 hasIssue "4" @default.
• W609537162 hasLocation W6095371621 @default.
• W609537162 hasLocation W6095371622 @default.
• W609537162 hasOpenAccess W609537162 @default.
• W609537162 hasPrimaryLocation W6095371621 @default.
• W609537162 hasRelatedWork W1897701706 @default.
• W609537162 hasRelatedWork W2016647631 @default.
• W609537162 hasRelatedWork W2042660006 @default.
• W609537162 hasRelatedWork W2044747643 @default.
• W609537162 hasRelatedWork W2052736117 @default.
• W609537162 hasRelatedWork W2077998387 @default.
• W609537162 hasRelatedWork W2126797993 @default.
• W609537162 hasRelatedWork W2151139437 @default.

• next