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- W60956479 abstract "Abstract After activation, CD4+ helper T (Th) cells differentiate into distinct effector lineages. Th cell subset called T follicular helper (TFH) cells are recently found to be present in germinal centers and are characterized by their expression of chemokine (C-X-C motif) receptor 5 (CXCR5). Despite their potential importance in humoral immunity, the developmental regulation of TFH cells and their relationship with other Th subsets is unclear. We found that mouse TFH cells have a divergent gene expression profile from Th1, Th2 cells, and in vivo developed independently of these cell lineages. TFH cell generation was regulated by ICOS liagand expressed on B cells and was dependent on interleukin (IL)-21, IL-6 and signal transducer and activator of transcription 3 (STAT3). Although TFH cells shared IL-21 expression with Th17 cells, they did not express IL-17, IL-17F, IL-22. Moreover, differentiation of TFH cells did not require TGFβ or Th17-specific orphan nuclear receptors RORα?and RORγ in vivo. Most importantly, T cells activated in vitro in the presence of IL-21 but without TGFβ signaling preferentially acquired TFH gene expression and functioned to promote humoral immunity in vivo. Our data indicate that TFH cells are distinct in their gene expression, developmental regulation and immune function from Th1, Th2 or Th17 lineages. The work is supported by a Scientist Development Grant from the American Heart Association." @default.
- W60956479 created "2016-06-24" @default.
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- W60956479 date "2009-04-01" @default.
- W60956479 modified "2023-09-25" @default.
- W60956479 title "Developmental requirements of T follicular helper cells (90.10)" @default.
- W60956479 doi "https://doi.org/10.4049/jimmunol.182.supp.90.10" @default.
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