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- W609602612 abstract "The N-alkylation of 4-aminopyrimidine with a tetrahydro-3-aza-cyclopropa[c]inden-5-one, which is a model reaction of the pharmacophore of duocarmycins, was studied with a quantum chemical method. We consider two factors for the acceleration of the N-alkylation; distortion and protonation of the model pharmacophores. The distortion of the spirocyclopropyl moiety in the model spirocyclopropylcyclohexadienone could induce an intrinsic energy of 3-4 kcal/mol, but the protonation on the carbonyl oxygen of the model cyclohexadienone lowers the transition energy of the N-alkylation of 4-aminopyrimidine dramatically (~46 kcal/mol) and is considered to play a major role in the enzyme reaction. The distor ted and protonated spirocyclohexadienone is exothermally relieved to a phenol with the heat of r eaction of -37 kcal/mol. The protonation process is proposed to be the mode of action of duocarmycins in the DNA alkylation." @default.
- W609602612 created "2016-06-24" @default.
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- W609602612 date "2004-01-20" @default.
- W609602612 modified "2023-09-25" @default.
- W609602612 title "A Theoretical Study on the N-Alkylation of a Pyrimidine with a Cyclopropa[c]inden-5-one; A Model Pharmacophore of Duocarmycins and CC-1065" @default.
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- W609602612 doi "https://doi.org/10.5012/bkcs.2004.25.1.069" @default.
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